Results 51 to 60 of about 58,988 (219)

Modeling Supports Combinatorial Effects Between Pharmacological and Non‐Pharmacological Interventions to Prevent Opioid‐Induced Cardiac Arrest

Clinical Pharmacology &Therapeutics, EarlyView.
Few studies have quantified the effects of non‐pharmacological interventions (e.g., rescue breathing) in the setting of community opioid overdose. We extended a previously validated model for opioid antagonists by incorporating the mechanism of rescue breathing, and quantified combinatorial effects between rescue breathing and various formulations of ...
Bradlee Thrasher, John Mann, Anik Chaturbedi, Shilpa Chakravartula, Hamed Meshkin, Affan Affan, Alexander Galluppi, Ji Young Kim, Nigar Karimli, Yue Han, Zachary Dezman, Jeffry Florian, Zhihua Li   +12 more
wiley   +1 more source

Ischemic priapism as a model of exhausted metabolism

Physiological Reports, 2019
In vivo metabolic studies typically concern complex open systems. However, a closed system allows better assessment of the metabolic limits. Ischemic priapism (IP) constitutes a special model of the compartment syndrome that allows direct sampling from a
Sanne Vreugdenhil, Pedro J. Freire Jorge, Mels F. van Driel, Maarten W. Nijsten   +3 more
doaj   +1 more source

Extracorporeal Carbon Dioxide Removal Using a Renal Replacement Therapy Platform to Enhance Lung-Protective Ventilation in Hypercapnic Patients With Coronavirus Disease 2019-Associated Acute Respiratory Distress Syndrome

Frontiers in Medicine, 2020
Coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome (ARDS) is associated with high mortality. Lung-protective ventilation is the current standard of care in patients with ARDS, but it might lead to hypercapnia, which is ...
Faeq Husain-Syed, Faeq Husain-Syed, Faeq Husain-Syed, Horst-Walter Birk, Jochen Wilhelm, Jochen Wilhelm, Jochen Wilhelm, Jochen Wilhelm, Claudio Ronco, Claudio Ronco, V. Marco Ranieri, Bianka Karle, Stefan Kuhnert, Khodr Tello, Khodr Tello, Khodr Tello, Matthias Hecker, Matthias Hecker, Rory E. Morty, Rory E. Morty, Rory E. Morty, Rory E. Morty, Susanne Herold, Susanne Herold, Susanne Herold, Oliver Kehl, Hans-Dieter Walmrath, Hans-Dieter Walmrath, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, István Vadász, István Vadász, István Vadász   +36 more
doaj   +1 more source

Undisplayed Bicarbonate ion Concentration in Arterial Blood Gas Analysis [PDF]

Journal of Clinical and Diagnostic Research, 2013
Blood bicarbonate ion concentration (BcHCO3 - ) is a vital parameter in the management of acid base disorders. In an arterial blood gas (ABG) analyzer, the BcHCO3 - is calculated from the values of pH and pCO2 .
Aditya Balakrishna Sathe, Manjiri Shashank Bhalkar   +1 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Successful perioperative management of living-donor liver transplantation for a patient with severe methylmalonic acidemia: a case report

JA Clinical Reports, 2018
Background Methylmalonic acidemia (MMAemia) is a rare hereditary disease affecting organic acid metabolism. It causes recurrent metabolic acidosis and secondary mitochondrial dysfunction, resulting in a poor prognosis. Liver transplantation (LT) has been
Akiko Hirotsu, Eriko Kusudo, Natsumi Mori, Yoshimitsu Miyai, Kengo Suzuki, Shuji Kawamoto, Kazuhiko Fukuda   +6 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Lactic Acidosis in Asthma: Report of Two Cases and Review of the Literature

Canadian Respiratory Journal, 2002
Lactic acidosis is commonly associated with states of hypoxia and decreased tissue perfusion. Elevated lactic acid levels have also been observed in individuals who are not septic and who are normotensive, but who have received systemic adrenergic ...
Suma Prakash, Sanjay Mehta
doaj   +1 more source