Results 111 to 120 of about 12,303,189 (383)

Epidemiology, virology, and clinical features of severe acute respiratory syndrome -coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19)

Clinical and experimental pediatrics, 2020
A cluster of severe pneumonia of unknown etiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was isolated from lower respiratory tract sample as ...
Su Eun Park
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

One-step diagnosis of infection and lung cancer using metagenomic sequencing

Respiratory Research
Background Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious
Shaoqiang Li, Yangqing Zhan, Yan Wang, Weilong Li, Xidong Wang, Haoru Wang, Wenjun Sun, Xuefang Cao, Zhengtu Li, Feng Ye   +9 more
doaj   +1 more source

Idiopathic pleuroparenchymal fibroelastosis in a patient with pectus excavatum: an overlooked association

Asian Journal of Internal Medicine
Pleuroparenchymal fibroelastosis (PPFE) is a rare, progressive interstitial lung disease characterised by prominent upper lobe fibrosis and elastotic changes. Its aetiology remains unclear, with most cases classified as idiopathic.
K. Maduranga, A. P. D. Manodhya, S. Palihawadene, E. Perara   +3 more
doaj   +1 more source

Long-term exposure to ambient ultrafine particles and respiratory disease incidence in in Toronto, Canada: a cohort study

Environmental Health, 2017
BackgroundLittle is known about the long-term health effects of ambient ultrafine particles (
S. Weichenthal, Li Bai, M. Hatzopoulou, Keith Van Ryswyk, J. Kwong, M. Jerrett, A. van Donkelaar, R. Martin, R. Burnett, Hong Lu, Hong Chen   +10 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The air we breathe [PDF]

, 1993
Air pollution has been associated with respiratory ill health for centuries and in recent years much research effort has gone into quantifying the risks and elucidating the mechanisms. Respiratory disease, mostly of the airways is second only by a narrow
Ebejer, Martin J.
core  

The Breathing, Thinking, Functioning clinical model: a proposal to facilitate evidence-based breathlessness management in chronic respiratory disease

npj Primary Care Respiratory Medicine, 2017
Refractory breathlessness is a highly prevalent and distressing symptom in advanced chronic respiratory disease. Its intensity is not reliably predicted by the severity of lung pathology, with unhelpful emotions and behaviours inadvertently exacerbating ...
A. Spathis, S. Booth, Catherine Moffat, R. Hurst, R. Ryan, Chloe Chin, J. Burkin   +6 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The Number of Coronavirus Disease 2019 Vaccine Doses and Severe Clinical Outcomes in Older Patients Infected With a Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant [PDF]

, 2022
Koichi Furukawa, Yukiya Kurahashi, Hanako Ishimaru, Mitsuhiro Nishimura, Jun Arii, Shigeru Sano, Yoshiki Tohma, Hiroyuki Ohkita, Sachiko Nakamura, Sachiyo Iwata, Yasuko Mori   +10 more
openalex   +1 more source