Results 201 to 210 of about 1,199,457 (266)

Preclinical Evidence and Mechanisms of Traditional Chinese Medicine Polysaccharides Regulating the Gut-Lung Axis via Gut Microbiota in Respiratory Diseases. [PDF]

Nutrients
Rong XQ, Zhang XM, Lu C, Tan Y.
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Lung organoids for respiratory diseases: overcoming translational hurdles in drug discovery and safety assessment. [PDF]

Front Bioeng Biotechnol
Mao X, Cai M, Fan B.
europepmc   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Trained immunity in respiratory diseases: Mechanisms of action and intervention strategies. [PDF]

Chin Med J Pulm Crit Care Med
Lee SY, Li J, Zhou X.
europepmc   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

The importance of mechanical forces in chronic respiratory diseases. [PDF]

Eur Respir Rev
Burgess JK, Nawroth JC, Ibáñez-Fonseca A, Gavara N.   +3 more
europepmc   +1 more source

Unpacking the influence of ICT on respiratory diseases in Sub-Saharan Africa. [PDF]

Sci Rep
Luo H, Zhang L, Sun Y, Zhang L.
europepmc   +1 more source

Herbal Polyphenolic Mixtures as Antioxidant and Cytoprotective Agents in Respiratory Diseases: Molecular Mechanisms and Therapeutic Perspectives. [PDF]

Int J Mol Sci
Sergazy S, Shulgau Z, Nurgaziyev M, Nurgaziyeva A, Baurzhan M, Kairgeldina S, Gulyayev A.   +6 more
europepmc   +1 more source

CAR-T therapy: Advances in respiratory diseases. [PDF]

Chin Med J Pulm Crit Care Med
Han H, Hu Y.
europepmc   +1 more source