Results 31 to 40 of about 1,199,457 (266)

Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity

Frontiers in Immunology, 2022
COVID-19 has emerged as a devastating disease in the last 2 years. Many authors appointed to the importance of kallikrein-kinin system (KKS) in COVID-19 pathophysiology as it is involved in inflammation, vascular homeostasis, and coagulation.
Enrique Alfaro, Elena Díaz-García, Elena Díaz-García, Sara García-Tovar, Ester Zamarrón, Ester Zamarrón, Alberto Mangas, Raúl Galera, Raúl Galera, Kapil Nanwani-Nanwani, Rebeca Pérez-de-Diego, Rebeca Pérez-de-Diego, Eduardo López-Collazo, Francisco García-Río, Francisco García-Río, Francisco García-Río, Carolina Cubillos-Zapata, Carolina Cubillos-Zapata   +17 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Safety and Efficacy of CT-Guided Lung Biopsy in Elderly Patients age 75 Years and Older: A Single-Centre Retrospective Comparative Study

Technology in Cancer Research & Treatment
Introduction CT-guided biopsy has good diagnostic accuracy, but adverse events such as pneumothorax are common. There are few reports on the safety and efficacy of CT-guided biopsy in the elderly.
Saiki Yoshimura MD, Osamu Kanai MD, Kohei Fujita MD, PhD, Naoki Fujimoto MD, Yuta Okada MD, Shogo Toyama MD, Takanori Ito MD, Takuma Imakita MD, Issei Oi MD, PhD, Kiminobu Tanizawa MD, PhD   +9 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Characterization of Post COVID‑19 pneumo‑hematocele in the largest COVID-19 center in Mexico City

Journal of Cardiothoracic Surgery
Background Surgical management of post-COVID pneumo-hematocele is uncommon, and evidence regarding outcomes and risk factors for complications following video-assisted thoracoscopic surgery (VATS) is limited.
Guillermo Edmundo Castrillo-Hernández, Adriana Simoneta Pimienta-Ibarra, Edwin Gustavo Barrientos-Morales, Andrea Gloria Solares-Espinoza, Vanessa Dávila-Conn, Carmen Margarita Hérnandez-Cárdenas, Armando Roberto Castorena-Maldonado, Francina Valezka Bolaños, Alma Lilia Juárez-Armenta   +8 more
doaj   +1 more source

Endpoints in respiratory diseases [PDF]

European Journal of Clinical Pharmacology, 2010
A wide range of outcome measures or endpoints has been used in clinical trials to assess the effects of treatments in paediatric respiratory diseases. This can make it difficult to compare treatment outcomes from different trials and also to understand whether new treatments offer a real clinical benefit for patients.
DE BENEDICTIS FM, GUIDI R, CARRARO, SILVIA, BARALDI, EUGENIO   +3 more
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Endothelial dysfunction and persistent inflammation in severe post-COVID-19 patients: implications for gas exchange

BMC Medicine
Background Understanding the enduring respiratory consequences of severe COVID-19 is crucial for comprehensive patient care. This study aims to evaluate the impact of post-COVID conditions on respiratory sequelae of severe acute respiratory distress ...
Enrique Alfaro, Elena Díaz-García, Sara García-Tovar, Raúl Galera, Raquel Casitas, María Torres-Vargas, Cristina López-Fernández, José M. Añón, Francisco García-Río, Carolina Cubillos-Zapata   +9 more
doaj   +1 more source