Results 51 to 60 of about 1,199,457 (266)

Frequency of multi-drug resistance and mutations in Mycobacterium tuberculosis isolates from Punjab state of India

Journal of Epidemiology and Global Health, 2017
Data regarding prevalence of multi-drug resistant tuberculosis (MDR-TB) and associated common mutations is scarce from Punjab region. The study was designed to determine rate of MDR-TB among presumptive MDR-TB from Punjab and mutation patterns using ...
Ritu Singhal, Jyoti Arora, Grish C. Sah, Manpreet Bhalla, Rohit Sarin, Vithal Prasad Myneedu   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Physical activity levels and influencing factors in individuals with bronchiectasis: a cross-sectional study

Monaldi Archives for Chest Disease
Bronchiectasis is a chronic respiratory condition characterized by irreversible bronchial dilatation, persistent airway inflammation, and impaired mucociliary clearance. Physical activity (PA) plays a key role in improving respiratory health and quality
Vitaliano Nicola Quaranta, Maria Rosaria Vulpi, Andrea Portacci, Marianna Ardito, Sara Piccinno, Marianna Cicchetti, Silvano Dragonieri, Sebastiano Spierto, Emanuela Resta, Giovanna Elisiana Carpagnano   +9 more
doaj   +1 more source

Author Correction: Mir-21 Mediates the Inhibitory Effect of Ang (1–7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts

Scientific Reports, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Na-Na Sun, Chang- Hui Yu, Miao-Xia Pan, Yue Zhang, Bo-Jun Zheng, Qian- Jie Yang, Ze -Mao Zheng, Ying Meng   +7 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses

Drug Delivery, 2018
Avian influenza virus infection is a serious public health threat and preventive vaccination is the most cost-effective public health intervention strategy.
Weiping Cao, Margarita Mishina, Samuel Amoah, Wadzanai P. Mboko, Caitlin Bohannon, James McCoy, Suresh K. Mittal, Shivaprakash Gangappa, Suryaprakash Sambhara   +8 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency

BMC Pulmonary Medicine
Background Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD).
Minghui Shi, Shiwei Qumu, Siyuan Wang, Yaodie Peng, Lulu Yang, Ke Huang, Ruoxi He, Feng Dong, Hongtao Niu, Ting Yang, Chen Wang   +10 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

All-Cause and Cause-Specific Mortality in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

International Journal of COPD
Guixiang Zhao,1,2 Lu Wang,1– 3 Siyuan Lei,1– 3 Ya Li,1,2 Jiansheng Li,1– 3 Zhenzhen Feng1– 3 1Department of Respiratory Diseases, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China; 2The ...
Zhao G, Wang L, Lei S, Li Y, Li J, Feng Z   +5 more
doaj