Results 61 to 70 of about 1,166,270 (266)

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency

BMC Pulmonary Medicine
Background Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD).
Minghui Shi, Shiwei Qumu, Siyuan Wang, Yaodie Peng, Lulu Yang, Ke Huang, Ruoxi He, Feng Dong, Hongtao Niu, Ting Yang, Chen Wang   +10 more
doaj   +1 more source

Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses

Drug Delivery, 2018
Avian influenza virus infection is a serious public health threat and preventive vaccination is the most cost-effective public health intervention strategy.
Weiping Cao, Margarita Mishina, Samuel Amoah, Wadzanai P. Mboko, Caitlin Bohannon, James McCoy, Suresh K. Mittal, Shivaprakash Gangappa, Suryaprakash Sambhara   +8 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Respiratory diseases [PDF]

Postgraduate Medical Journal, 1990
D G, James, O M, Sharma
openaire   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

All-Cause and Cause-Specific Mortality in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

International Journal of COPD
Guixiang Zhao,1,2 Lu Wang,1– 3 Siyuan Lei,1– 3 Ya Li,1,2 Jiansheng Li,1– 3 Zhenzhen Feng1– 3 1Department of Respiratory Diseases, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China; 2The ...
Zhao G, Wang L, Lei S, Li Y, Li J, Feng Z   +5 more
doaj  

LncRNA RP11-86H7.1 promotes airway inflammation induced by TRAPM2.5 by acting as a ceRNA of miRNA-9-5p to regulate NFKB1 in HBECS

Scientific Reports, 2020
Traffic-related air pollution particulate matter 2.5 (TRAPM2.5), is involved in chronic obstructive pulmonary disease (COPD), which is characterized by airway inflammation.
Jun Zhao, Jinding Pu, Binwei Hao, Lingmei Huang, Jinglong Chen, Wei Hong, Yumin Zhou, Bing Li, Pixin Ran   +8 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Early trajectory of inflammatory cytokines following tarlatamab administration in three advanced SCLC patients

Cancer Immunology, Immunotherapy
Tarlatamab, a bispecific T-cell engager (BiTE), effectively activates the immune system but often causes cytokine release syndrome (CRS). To understand the early in vivo cytokine dynamics of post-BiTE therapy, we analyzed serum from three SCLC patients ...
Takuma Imakita, Kohei Fujita, Yuki Yamamoto, Osamu Kanai, Yuta Okada, Shogo Toyama, Takanori Ito, Issei Oi, Kiminobu Tanizawa   +8 more
doaj   +1 more source