Results 71 to 80 of about 1,166,270 (266)

An uncommon cause of pneumonia: The golden diagnosis

Respiratory Medicine Case Reports, 2017
A 28-year-old sub-Saharan African Italian non-smoker male presented with signs and symptoms of pneumonia and respiratory failure. Despite antibiotic treatment he experienced a significant worsening of respiratory conditions and admission to intensive ...
Laura Fabbri, Roberto Tonelli, Alessandro Andreani, Ivana Castaniere, Riccardo Fantini, Alessandro Marchioni, Enrico M. Clini   +6 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Diagnostic Yield of Nontuberculous Mycobacteria Testing in Patients with Chronic Lung Diseases: A Retrospective Cohort Study

Infection and Drug Resistance
Mateja Jankovic Makek,1,2 Ena Tolic,2 Christoph Lange,3– 6 Matea Zvonar,2 Dora Darapi Marušić,2 Ivana Marekovic,1,7 Sonja Badovinac,2 Goran Glodic,2 Kristijan Marcic,1 Nika Zielinski,3– 5 Maja Reimann3– 5 1School of Medicine, University of ...
Jankovic Makek M, Tolic E, Lange C, Zvonar M, Darapi Marušić D, Marekovic I, Badovinac S, Glodic G, Marcic K, Zielinski N, Reimann M   +10 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Vaccine Effectiveness Estimates Against Influenza A(H3N2)-Associated Hospitalized Severe Acute Respiratory Infections in Beijing, China, 2025/26 Influenza Season

Vaccines
Background: Data on influenza vaccine effectiveness (VE) against hospitalized severe acute respiratory infection (SARI), particularly in Asia, remain limited for the 2025/26 Northern Hemisphere influenza season. This study aimed to evaluate real-world VE
Chunna Ma, Jiaojiao Zhang, Jiaxin Ma, Wei Duan, Yingying Wang, Xiaodi Hu, Jia Li, Lu Zhang, Yuanzhi Di, Shuning Yan, Peng Yang, Quanyi Wang, Ying Shen, Daitao Zhang   +13 more
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Association of Systemic Inflammatory Response Index with Disease Severity and Adverse Outcome in Chronic Thromboembolic Pulmonary Hypertension

Journal of Inflammation Research
Sicong Li,* Luyang Gao,* Sicheng Zhang,* Qing Zhao, Tao Yang, Anqi Duan, Yijia Wang, Qi Wang, Zhihui Zhao, Qin Luo, Zhihong Liu Center for Respiratory and Pulmonary Vascular Diseases, Fuwai Hospital, National Center for ...
Li S, Gao L, Zhang S, Zhao Q, Yang T, Duan A, Wang Y, Wang Q, Zhao Z, Luo Q, Liu Z   +10 more
doaj  

Single-centre retrospective experience of complications and outcomes of computed tomography-guided lung biopsy and interventions for the management of intrathoracic infections

BMC Research Notes
Objective To investigate the complications and outcomes of computed tomography (CT)-guided lung biopsy and interventions in the management of intrathoracic infections. Results Twenty-nine patients were examined.
Kohei Fujita, Naoki Fujimoto, Saiki Yoshimura, Shogo Toyama, Takanori Ito, Takuma Imakita, Issei Oi, Osamu Kanai, Yuki Yamamoto, Kiminobu Tanizawa   +9 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source