Results 91 to 100 of about 1,251,104 (291)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Incidence and risk factors for respiratory syncytial virus and human metapneumovirus infections among children in the remote highlands of Peru [PDF]

, 2015
The disease burden and risk factors for respiratory syncytial virus (RSV) and human metapneumovirus (MPV) infections among children living in remote, rural areas remain unclear.; We conducted a prospective, household-based cohort study of children aged ...
Gil, Ana I., Philip J Budge, Kathryn M. Edwards (534416), Verastegui, Hector, Yuwei Zhu, Hector Verastegui, Grijalva, Carlos G, Carlos G. Grijalva, Grijalva, Carlos G., Stella Hartinger, Stella Hartinger (759804), Gil, Ana I, Marie R Griffin, Griffin, Marie R., Wu, Andrew, Lanata, Claudio F., Marie R. Griffin (209725), Marie R. Griffin, Monika Johnson, Ana I. Gil, Philip J. Budge (389401), Williams, John, Andrew Wu, Carlos G. Grijalva (236548), John Williams (32544), Zhu, Yuwei, Claudio F Lanata, Hector Verastegui (534417), Kathryn M Edwards, Andrew Wu (90389), Edwards, Kathryn M, John Williams, Yuwei Zhu (236550), Budge, Philip J, Johnson, Monika, Hartinger, Stella, Ana I. Gil (534420), Lanata, Claudio F, Ana I Gil, Claudio F. Lanata, Edwards, Kathryn M., Philip J. Budge, Griffin, Marie R, Carlos G Grijalva, Andrew Wu, Kathryn M. Edwards, Claudio F. Lanata (454212), Monika Johnson (12861), Budge, Philip J.   +48 more
core   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

National Center for Immunization and Respiratory Diseases (NCIRD) Office of the Director [PDF]

The mission of the National Center for Immunization and Respiratory Diseases (NCIRD) is to prevent disease, disability, and death through immunization and by control of respiratory and related diseases.2022-ncird-recruiting-flyer-od-508 ...

core  

Microbiological Etiology and Detection of Drug-Resistant Bacteria in Pneumonia in Patients with Organophosphate Poisoning in the Intensive Care Unit

Infection and Drug Resistance
Naoto Kanno,1,2 Yuuki Bamba,1,2 Shimon Aoki,1,2 Ikumi Yamagishi,1 Masahiro Ui,1 Hayato Tsuruma,1 Mariko Hakamata,1 Hideyuki Ogata,1 Satoshi Shibata,1 Kou Matsui,2 Hiromi Cho,1 Mizuho Sato,1 Nobumasa Aoki,1 Hiroshi Moro,1 Toshiyuki Koya,1 Kei Nishiyama,2 ...
Kanno N, Bamba Y, Aoki S, Yamagishi I, Ui M, Tsuruma H, Hakamata M, Ogata H, Shibata S, Matsui K, Cho H, Sato M, Aoki N, Moro H, Koya T, Nishiyama K, Kikuchi T   +16 more
doaj  

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis

Nature Communications, 2019
Meningitis is a severe form of invasive pneumococcal disease (IPD). To study the contribution of bacterial genomic variation, here Li et al. perform whole genome sequencing of pneumococcal isolates from IPD patients and identify an association for higher
Yuan Li, Benjamin J. Metcalf, Sopio Chochua, Zhongya Li, Hollis Walker, Theresa Tran, Paulina A. Hawkins, Ryan Gierke, Tamara Pilishvili, Lesley McGee, Bernard W. Beall   +10 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source