Results 51 to 60 of about 1,074,013 (250)

Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus

, 2008
Polymyositis and interstitial lung diseases, predominantly nonspecific interstitial pneumonia (NSIP), are known to be frequent in antisynthetase syndrome, where anti-aminoacyl-tRNA synthetase antibodies are often identified.
Merz, T M, Suter, C, Nicod, L P, Gugger, M, Guglielmi, S, Gugger M, Nicod, Laurent, Nicod LP, Merz TM, Suter C, Gugger, Mathias, Guglielmi S, Merz, Tobias   +12 more
core   +1 more source

Topics in acute respiratory distress syndrome: the patient needs our tender loving and care [PDF]

, 2014
This editorial introduces a four-part series on acute respiratory distress syndrome (ARDS) that will cover a wide range of related topics in reviews written by internationally renowned experts.
Price, Laura, Laura Price, L. Price, Stefano Nava, S. John Wort, S. J. Wort, NAVA, STEFANO, Wort, S. John   +7 more
core   +2 more sources

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Acute Respiratory Distress in Cattle

, 1989
Acute respiratory distress is a common problem to the bovine practitioner. Acute respiratory distress can be categorized into upper respiratory disease or lower respiratory disease. Since dyspnea is the primary clinical sign in cases of acute respiratory
Kersting, K., Thompson, J.
core   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction

Frontiers in Immunology
IntroductionSepsis is a life-threatening organ dysfunction syndrome with persistently high global mortality, driven by dysregulated host immune response.
Jiawen Duan, Jiawen Duan, Lingyu Jiang, Kunlin Hu, Huirong Shi, Xinyu Chi, Xinyu Chi, Weiting Feng, Guodong Wang, Shulin Xiang, Shulin Xiang, Bin Xiong, Bin Xiong, Bin Xiong   +13 more
doaj   +1 more source

Outcome of Respiratory distress in Neonates with Bubble CPAP at Neonatal Intensive Care Unit of a Tertiary Hospital

Journal of Nepal Medical Association, 2019
Introduction: Respiratory distress is one of the commonest problem seen in neonates during admission in Neonatal Intensive Care Unit. Hyaline Membrane disease, Meconium Aspiration Syndrome, septicemia, congenital pneumonia, Transient Tachypnea of Newborn
Sunil Raja Manandhar
doaj   +1 more source

Etiological profile of upper airway obstruction in infants

The Egyptian Journal of Otolaryngology, 2020
Background Respiratory distress is recognized as any sign of breathing difficulty in infants. Some congenital anomalies present immediately with airway distress, while others are asymptomatic or discovered later in infancy or childhood.
Essam Abo Elmagd, Bahaa El Hawary, Megahed M. Hassan, Hanem Kassem, Abd El Rahman El Tahan   +4 more
doaj   +1 more source

Prone position in acute respiratory distress syndrome

, 2002
In the last few years prone positioning has been used increasingly in the treatment of patients with acute respiratory distress syndrome (ARDS) and this manoeuvre is now considered a simple and safe method to improve oxygenation.
PELOSI, PAOLO PASQUALINO, BRAZZI L, L. Brazzi, P. Pelosi, GATTINONI L., Brazzi, Luca, L. Gattinoni   +6 more
core   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source