Results 61 to 70 of about 182,776 (202)

Menthol inhalation relieves dyspnoea through the brain

ERJ Open Research
Background Menthol inhalation (MI) relieves dyspnoea in healthy individuals and people with respiratory disorders, independent of changes in breathing patterns and respiratory muscle electromyography activity. Thus, the underlying working mechanism of MI
Lucas Vanden Bossche, Samantha Piers, Michele R. Schaeffer, Valentina Jelinčić, Kristin Verbeke, Clara Batsleer, Lotte Albert, Dennis Jensen, Wim Janssens, Thierry Troosters, Daniel Langer, Andreas von Leupoldt   +11 more
doaj   +1 more source

The interplay between sleep and neural respiratory drive in COPD: contribution of semi-automated analysis of long duration recordings

NeuroImage
Background: Neural respiratory drive (NRD) is a clinically relevant biomarker in patients with chronic obstructive pulmonary disease (COPD). However, its analysis is challenging due to several technical considerations, including the need to obtain a ...
Léo Grassion, Maxime Patout, Nicolas Wattiez, Stefania Redolfi, Isabelle Arnulf, Thomas Similowski, Thomas Andrillon, Jésus Gonzalez-Bermejo   +7 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Drive respiratório anormal na doença vibroacústica Abnormal respiratory drive in vibroacoustic disease

Revista Portuguesa de Pneumologia, 2006
Enquadramento: As alterações do sistema nervoso central em trabalhadores expostos a ruído de baixa frequência (RBF, 60%). Conclusões:Na resposta reflexa ao acréscimo de PCO2, os quimio-receptores centrais são responsáveis por 70% do estímulo ventilatório.
José Reis Ferreira, José Albuquerque e Sousa, Peter Foreid, Marco Antunes, Sofia Cardoso, Mariana Alves-Pereira, Nuno A A Castelo Branco   +6 more
doaj  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Mechanisms associated with progression from lobar inflammation to bilateral lung injury: an experimental study

Respiratory Research
Background Localized lung insult, such as pneumonia, can increase respiratory drive and effort. The interplay between the initial injury, the inflammatory reaction and increased drive and effort could damage other areas and progress to bilateral lung ...
Tommaso Mauri, Elena Spinelli, Ines Marongiu, Anna Damia, Marco Leali, Alice Maretti, Leonardo Consalvo, Francesco Damarco, Gianluca Lopez, Alberto Zanella, Lorenzo Rosso, Valentina Vaira, Giacomo Grasselli   +12 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source