Results 51 to 60 of about 2,054,297 (223)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Accuracy of P0.1 measurements performed by ICU ventilators: a bench study

Annals of Intensive Care, 2019
Background Occlusion pressure at 100 ms (P0.1), defined as the negative pressure measured 100 ms after the initiation of an inspiratory effort performed against a closed respiratory circuit, has been shown to be well correlated with central respiratory ...
François Beloncle, Lise Piquilloud, Pierre-Yves Olivier, Alice Vuillermoz, Elise Yvin, Alain Mercat, Jean-Christophe Richard   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Pulse transit time as a measure of respiratory effort under noninvasive ventilation

, 2013
Among the respiratory events that may occur during nocturnal noninvasive ventilation (NIV), differentiating between central and obstructive events requires appropriate indicators of respiratory effort.
Sabil, AbdelKébir, Tamisier, Renaud, Lévy, Patrick, Janssens, Jean-Paul, Pépin, Jean-Louis, Borel, Jean-Christian, Contal, Olivier, Carnevale, Claudio   +7 more
core   +1 more source

Comparative Analysis of Electrode Configurations for Estimating Respiratory Effort From Diaphragmatic Electromyography

IEEE Open Journal of Instrumentation and Measurement
Accurate estimation of respiratory effort is essential for obstructive sleep apnea (OSA) assessment. The current gold standard is esophageal pressure (Pes); however, its intrusiveness makes it unsuitable for routine use.
Gabriela M. Gronska, Elisabetta Peri, Xi Long, Sebastiaan Overeem, Johannes P. van Dijk, Massimo Mischi   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Airway Occlusion Pressure As an Estimate of Respiratory Drive and Inspiratory Effort during Assisted Ventilation.

, 2020
Rationale: Monitoring and controlling respiratory drive and effort may help to minimize lung and diaphragm injury. Airway occlusion pressure (P0.1) is a noninvasive measure of respiratory drive.Objectives: To determine 1) the validity of "ventilator" P0 ...
Junhasavasdikul, D., Piquilloud, L., Chen, L., Rittayamai, N., Goligher, E.C., Telias, I., Brochard, L., Ferguson, N.D.   +7 more
core   +1 more source

ERS International Congress 2021: highlights from the Respiratory Clinical Care and Physiology Assembly [PDF]

, 2022
It is a challenge to keep abreast of all the clinical and scientific advances in the field of respiratory medicine. This article contains an overview of laboratory-based science, randomised controlled trials and qualitative research that were presented ...
Matthew Armstrong, Vitalii Poberezhets, Evans, Rachael A., Kolekar, Shailesh B, Thomas Gille, Armstrong, M., Franssen, Frits M.E., Cláudia Vicente, Camille Rolland-Debord, Franssen, Frits M. E., Hilary Pinnock, Vicente, Cláudia, Georgios Kaltsakas, Gille, T., Tuffnell, R., Kolekar, Shailesh B., Bayat, S., Rachel Tuffnell, Vanfleteren, Lowie E G W,, Das, N., Vogiatzis, I., Poberezhets, V., Vogiatzis, Ioannis, Rolland-Debord, C., Sivapalan, Pradeesh, Tuffnell, Rachel, Nilakash Das, Armstrong, Matthew, Kolekar, S. B., Luiza Helena Degani-Costa, Degani-Costa, L. H., Lowie E.G.W. Vanfleteren, Evans, Rachael A, Vanfleteren, Lowie E.G.W., Das, Nilakash, Degani-Costa, Luiza Helena, Poberezhets, Vitalii, Vagheggini, G., Vanfleteren, Lowie E. G. W., Pinnock, H., Vanfleteren, Lowie E G W, Pinnock, Hilary, Guido Vagheggini, Bayat, Sam, Vicente, C., Rolland-Debord, Camille, Gille, Thomas, Kaltsakas, Georgios, Pinnock, Hilary; id_orcid, Franssen, F. M. E., Shailesh B. Kolekar, Frits M.E. Franssen, Kaltsakas, G., Franssen, Frits ME, Vagheggini, Guido, Pradeesh Sivapalan, Ioannis Vogiatzis, Franssen, Frits M E, Degani-Costa, Luiza, Rachael A. Evans, Sam Bayat, Sivapalan, P., Evans, R. A.   +62 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source