Results 241 to 250 of about 1,085,335 (335)

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Practices of high-flow nasal therapy in acute and chronic respiratory failure: the Hi-Flow Survey. [PDF]

BMJ Open Respir Res
Crimi C, Noto A, Cortegiani A, Carlucci A, Gregoretti C, Inal-Ince D, Franssen FMEME, Karagiannidis C, Winck JC, Fisser C, Ergan B, Martin-Loeches I, Cysneiros A, Patout M, Duiverman M, Nava S.   +15 more
europepmc   +1 more source

Non‐Invasive Assessment of Respiratory Mechanics Using Anatomical M‐Mode Ultrasound in Acute Pulmonary Oedema With Impending Respiratory Failure: A Case Report [PDF]

Timothy Kangwei Wong, Albert Yick Hou Lim, Lee Chiao Hao   +2 more
openalex   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Confronting Hypoxemic Respiratory Failure in Africa: If Not Now, When? [PDF]

Ann Am Thorac Soc
Cummings MJ, Bakamutumaho B.
europepmc   +1 more source

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

Optimising time-limited trials in acute respiratory failure: a multicentre focused ethnography protocol. [PDF]

BMJ Open
Kruser JM, Wiegmann DA, Nadig NR, Secunda KE, Hanlon BM, Moy JX, Ahmad A, Campbell EG, Donnelly HK, Martinez FJ, Polley M, Orhan C, Korth E, Stalter LN, Rowe TJ, Wu AL, Viglianti EM, Eisinger EC, Nguyen O, Halpern SD, Clapp JT.   +20 more
europepmc   +1 more source

The risk factors for late failure of non-invasive mechanical ventilation in acute hypercapnic respiratory failure

, 2014
Aydın Çiledağ, Akın Kaya, Adem İlkay Diken, Zeynep Pınar Önen, Elif Şen, Nalan Demir   +5 more
openalex   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Trimethoprim-Sulfamethoxazole and Acute Respiratory Failure in Adolescents and Young Adults.

JAMA Netw Open
Ahmadi F, McArthur E, Garcia-Bournissen F, Rieder MJ, Muanda FT.   +4 more
europepmc   +1 more source