Results 71 to 80 of about 5,815,326 (246)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Evaluation of computed tomography in the diagnosis of ultrasound-proven diaphragm dysfunction

Respiratory Research
Introduction Computed tomography (CT) is routinely employed on the evaluation of dyspnea, yet limited data exist on its assessment of diaphragmatic muscle.
Pauline Lallement, Alain Boussuges, Paul Habert, Julien Bermudez, Martine Reynaud-Gaubert, Stéphane Delliaux, Fabienne Bregeon, Benjamin Coiffard   +7 more
doaj   +1 more source

Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD

International Journal of Endocrinology, 2012
In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli.
Alfredo Chetta, Dario Olivieri
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Respiratory sleep disturbance in children and adolescents with cystic fibrosis

Revista Portuguesa de Pneumologia (English Edition), 2016
Sleep disturbance has been described in cystic fibrosis (CF) patients as relevant to clinical and lung function predictive factors helping to improve the diagnosis and early intervention. Related paediatric studies are scarce.
A.M. Silva, A. Descalço, M. Salgueiro, L. Pereira, C. Barreto, T. Bandeira, R. Ferreira   +6 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Parental smoking and lung function in children: an international study.

, 2006
RATIONALE: Both prenatal and postnatal passive smoking have been linked with respiratory symptoms and asthma in childhood. Their differential contributions to lung function growth in the general children's population are less clear.
Hruba, F., Antova, Temenuga, Moshammer, Hanns, Luttmann-Gibson, H., Slachtova, H., Pattenden, Sam, Zlotkowska, Renata, Neuberger, M.A., Fletcher, T., Antova, T., Gehring, Ulrike, Hruba, Frantiska, Hoek, G., Neuberger, Manfred A, Pattenden, S., Fletcher, Tony, Rudnai, P., Rudnai, Peter, Slachtova, Hana, Moshammer, H., Gehring, U., Hoek, Gerard, Zlotkowska, R., Luttmann-Gibson, Heike   +23 more
core   +1 more source

Clinical Usefulness of Response Profiles to Rapidly Incremental Cardiopulmonary Exercise Testing

Pulmonary Medicine, 2013
The advent of microprocessed “metabolic carts” and rapidly incremental protocols greatly expanded the clinical applications of cardiopulmonary exercise testing (CPET).
Roberta P. Ramos, Maria Clara N. Alencar, Erika Treptow, Flávio Arbex, Eloara M. V. Ferreira, J. Alberto Neder   +5 more
doaj   +1 more source

Expiratory Flow – Vital Capacity: Airway – Lung Dysanapsis in 7 Year Olds Born Very Preterm?

Frontiers in Physiology, 2018
An index normalizing airway dimension for lung size derived from spirometry was found inversely correlated to lung size in school children born very preterm, indicating larger alveolar volumes draining into comparatively smaller airways.
Iulia Ioan, Iulia Ioan, Aurore Gemble, Isabelle Hamon, Isabelle Hamon, Cyril Schweitzer, Cyril Schweitzer, Cyril Schweitzer, Stéphanie Metche, Claude Bonabel, Claude Bonabel, Phi L. Nguyen-Thi, Jean-Michel Hascoet, Jean-Michel Hascoet, Silvia Demoulin-Alexikova, Silvia Demoulin-Alexikova, François Marchal, François Marchal   +17 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source