Results 91 to 100 of about 2,309,617 (377)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Função pulmonar pós-colecistectomia laparoscópica e abreviado tempo anestésico-cirúrgico

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Avaliar a função pulmonar pós-colecistectomias laparoscópicas. MÉTODOS: Estudo prospectivo, onde se avaliaram espirometrias pós-operatórias de 15 pacientes submetidas à colecistectomias laparoscópicas por meio de um tempo anestésico-cirúrgico ...
Gilson Cassem Ramos, Edísio Pereira, Salustiano Gabriel Neto, Enio Chaves de Oliveira   +3 more
doaj   +1 more source

Uncertainty Analysis of Feature Extraction from Expired Gas Traces [PDF]

, 2000
Noninvasive medical analyses are a convenient method to study several pathologies even though their indirect nature often requires a complex processing to determine the relevant health "indicators".
Gulotta, C., Parvis, Marco, Torchio, R.
core   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Spirometric assessment of lung transplanted patients: one year follow-up

Brazilian Journal of Transplantation, 2008
Purpose: The purpose of this study was to compare spirometric data between patients submitted to single-lung and double-lung transplantation along the first year after the transplant procedure.
Paulo Pêgo-Fernandes, Fernando Conrado Abrão, Frederico Leon Arrabal Fernandes, Marlova Caramori, Marcos Naoyuki Samano, Fabio Jatene   +5 more
doaj   +1 more source

ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases [PDF]

, 2019
The objective of this document was to standardise published cardiopulmonary exercise testing (CPET) protocols for improved interpretation in clinical settings and multicentre research projects.
Aguilaniu, Armstrong, Asterios Kampouras, Beaver, Bell, Borg, Boyce, Campbell, Causer, Chris Burtin, Clark, Corra, Cranston, Crisafulli, Daniel Langer, Danilo Berton, Dillard, Dimitris Kontopidis, Dionne C.W. Braeken, Don S. Urquhart, Ernst Eber, Evans, Farley, Frits M.E. Franssen, Georgios Kaltsakas, Gift, Grant, Grenvik, Groepenhoff, Hartman, Hebestreit, Hebestreit, Helge Hebestreit, Holm, Huszczuk, Ioannis Vogiatzis, J. Alberto Neder, Jana De Brandt, Jeanette Boyd, Johns, Johnson, Johnson, Jones, Kor, Krahenbuhl, Loe, Martijn A. Spruit, McArdle, Miller, Milo A. Puhan, Miyamura, Myers, Nagle, Naughton, Ochmann, Orenstein, Palange, Peveler, Pierantonio Laveneziana, Porszasz, Richard Casaburi, Riddell, Ries, Roberto A. Rabinovich, Roman, Saey, Samuel Verges, Sarah Crook, Sauwaluk Dacha, Schaun, Sheehan, Siler, Stickland, Thierry Troosters, Thomas Radtke, Thomy Tonia, Wagner, Ward, Wasserman, Wasserman, Whipp, Williams, Wilmore, Yeh, Yoshiya, Yvonne M.J. Goërtz, Zafeiris Louvaris, Zeballos, Zhang   +88 more
core   +4 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Avaliação da função pulmonar após colecistectomias laparoscópicas e convencionais

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Avaliar a função pulmonar pós-colecistectomias laparoscópicas e subcostais abertas. MÉTODOS: Tratou-se de um ensaio randomizado, onde se avaliaram espirometrias pós-operatórias de dois grupos, cada qual com 15 pacientes.
Gilson Cassem Ramos, Edísio Pereira, Salustiano Gabriel Neto, Enio Chaves de Oliveira   +3 more
doaj   +1 more source

The Effect of Obesity Degree on Childhood Pulmonary Function Tests

Balkan Medical Journal, 2014
Background: Childhood obesity has become a global epidemic. It is related to several chronic diseases such as essential hypertension, type 2 diabetes mellitus, and renal disease.
Emel Torun, Fatma Özgüç, Erkan Cakir, İlker Tolga Özgen   +3 more
doaj   +1 more source

Impact of elosulfase alfa in patients with morquio A syndrome who have limited ambulation: An open-label, phase 2 study. [PDF]

, 2017
Efficacy and safety of elosulfase alfa enzyme replacement therapy (ERT) were assessed in an open-label, phase 2, multi-national study in Morquio A patients aged ≥5 years unable to walk ≥30 meters in the 6-min walk test.
Berger, Kenneth I, Burton, Barbara K, Decker, Celeste, Geberhiwot, Tarekegn, Harmatz, Paul R, Hendriksz, Christian J, Jameson, Elisabeth, Jester, Andrea, Mengel, Eugen, Muschol, Nicole, Sisic, Zlatko, Treadwell, Marsha   +11 more
core   +1 more source