Results 61 to 70 of about 662,929 (355)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

The Correlation Between Body Fat Percentage and Peak Expiratory Flow in Children Aged 10-12 Years at SD Negeri 8 Dauh Puri [PDF]

, 2019
Background: The accumulation of fat decreases lung function. Peak expiratory flow is an indicator for assessing pulmonary function and can be used to identify the narrowing or obstruction of the airway. This study aimed to examine the correlation between
Indahswari, N. W. (Ni), Indrayani, A. W. (Agung), Thanaya, S. A. (Sayu), Wibawa, A. (Ari)   +3 more
core   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Lung Function Assessment by Impulse Oscillometry in Adults

Therapeutics and Clinical Risk Management, 2020
Noemi Porojan-Suppini, Ovidiu Fira-Mladinescu, Monica Marc, Emanuela Tudorache, Cristian Oancea Department of Pulmonology, Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, University of Medicine and Pharmacy &ldquo ...
Porojan-Suppini N, Fira-Mladinescu O, Marc M, Tudorache E, Oancea C   +4 more
doaj  

Mainstream Capnography Correlates Well with Central Venous Carbon Dioxide Levels in Non-intubated Children in PACU [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Monitoring exhaled Carbon Dioxide (CO2 ) in nonintubated patients is challenging but has value for detecting hypoventilation, apnoea and hypercarbia. The study investigated a mainstream mask capnography system (cap-ONE®) especially designed
Abhishek Karnwal, Makoto Nagoshi, Rica Morzov, Justin Hotz, Allan Cresencia, Sameh Nour, Paula Belson, Patrick Ross   +7 more
doaj   +1 more source

Evaluation expérimentale de la fonction pulmonaire chez le porc [PDF]

, 2004
This synthesis aims to review the pulmonary function tests available in swine. Two techniques are used in order to measure the variations of the mechanical properties of the respiratory system.
Cambier, Carole, Gustin, Pascal, Halloy, D., Kirschvink, N.   +3 more
core  

A pilot study of zafirlukast as an anti-inflammatory agent in the treatment of adults with cystic fibrosis [PDF]

, 2003
Background: Persistent endobronchial inflammation is in part responsible for the attrition of lung function seen in cystic fibrosis. Leukotrienes act as pro-inflammatory mediators.
Conway, S.P., Etherington, C., Peckham, D.G., Whitehead, A.   +3 more
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Lung transplantation benefits for terminal lung diseases [PDF]

, 2011
peer reviewedLung transplantation is an established treatment of pulmonary diseases at an advanced stage. The purpose of our study is to present the benefits, indications and complications of this surgical procedure in the CHU of Liege.
CORHAY, Jean-Louis, DUYSINX, Bernard, LOUIS, Renaud, NGUYEN DANG, Delphine, PIRSON, J.   +4 more
core