Results 51 to 60 of about 1,031,791 (269)
Validation of the Finnish Severe Respiratory Insufficiency Questionnaire [PDF]
, 2020 Introduction Chronic respiratory insufficiency impacts patients? lives and reduces quality of life. The Severe Respiratory Insufficiency (SRI) questionnaire examines health-related quality of life and is designed specifically for patients receiving home ...
Kotanen, Petra +11 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
A previously healthy 45-year-old male with respiratory insufficiency caused by H1N1 pneumonitis
, 2010 We present the case of a previous healthy patient who suffered from severe respiratory insufficiency based on an H1N1v pneumonitis. He was admitted to ICU, intubated and mechanically ventilated. Eventually the patient recovered.
Alsma, J.; id_orcid +3 more
core +8 more sources
Congenital acinar dysplasia: a lethal entity
Autopsy and Case Reports, 2019 Congenital acinar dysplasia is a lethal, developmental lung malformation resulting in neonatal respiratory insufficiency. This entity is characterized by pulmonary hypoplasia and arrest in the pseudoglandular stage of development, resulting in the ...
Sabrina Oneto, Robert J. Poppiti
doaj +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
, 2016 A comparison between patients with respiratory insufficiency (n = 22, 42%) and those with normal respiratory function (n = 38, 58%).
Alain Duhamel (286617) +12 more
core +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
BMC Neurology, 2012 Background Motor neurone disease (MND) is a devastating illness which leads to muscle weakness and death, usually within 2-3 years of symptom onset.
McDermott Christopher J +20 more
doaj +1 more source
Molecular diagnosis and novel genes and phenotypes in a pediatric thoracic insufficiency cohort
Scientific Reports, 2023 Thoracic insufficiency syndromes are a genetically and phenotypically heterogeneous group of disorders characterized by congenital abnormalities or progressive deformation of the chest wall and/or vertebrae that result in restrictive lung disease and ...
Alanna Strong +14 more
doaj +1 more source