Results 111 to 120 of about 43,117 (251)

Monitoring respiratory mechanics as a training tool for manual ventilation. [PDF]

Front Pediatr
Carlomagno CEB, Mascaretti RS, Lyra JC, Zacharias RSB, Magalhaes M, Breuel PAF, Rebello CM.   +6 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Anatomical and Physiological Simulation for Respiratory Mechanics

, 1995
Injuries in trauma affect anatomical structures, indirectly affecting physiological systems through mechanical behavior and physical proximity. This paper describes the theory and preliminary results from our approach to couple a 3D anatomical model of ...
Dimitri Metaxas, Jr., Frank P. Primiano, Jonathan Kaye   +3 more
core  

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Is Measurement of Inspiratory Effort and Respiratory Mechanics before Ventilator Weaning a Step toward Personalized Medicine? [PDF]

Am J Respir Crit Care Med
Thille AW, Bichon A, Terzi N.
europepmc   +1 more source

Airway and respiratory tissue mechanics in normal infants

, 2000
Airway and respiratory tissue mechanics in normal ...
K Tiller (13369269), PR Burton (7652123), Z Hantos (13368084), F Petak (13369263), JH Wildhaber (14458632), PD Sly (14453628), GL Hall (14457465)   +6 more
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The clinical trade-off of intraluminal versus extraluminal bronchial blockers in children: a retrospective analysis of respiratory mechanics and airway trauma during lung isolation preparation. [PDF]

Front Pediatr
Gu Z, Zhu C, Wang G, Ren L, Wei S, Wei R.   +5 more
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Effect of prone positioning and PEEP on respiratory mechanics in children undergoing scoliosis surgery. [PDF]

J Anesth Analg Crit Care
Camporesi A, Cristiani F, Cruces P, Igarzabal H, Catozzi G, Bayon G, Fontans F, Falcao G, Odriozola S, Hammer J, Gonzalez-Dambrauskas S.   +10 more
europepmc   +1 more source