Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source
Cervical Spine Range of Motion Reliability with Two Methods and Associations with Demographics, Forward Head Posture, and Respiratory Mechanics in Patients with Non-Specific Chronic Neck Pain. [PDF]
Tatsios PI +5 more
europepmc +1 more source
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong +5 more
wiley +1 more source
Forced expiration technique: impact on the respiratory mechanics parameters of children and adolescents with cystic fibrosis. [PDF]
Keil PMR +4 more
europepmc +1 more source
Development of Teleoperated Robotic System for Remote Intraocular Microsurgery
A teleoperated robotic system, characterized by micrometer‐scale precision and a remote center of motion design, is developed and validated to ensure the safety and flexibility of remote intraocular surgery. This system exhibits superior performance in experimental evaluations and holds significant potential for advancing remote microsurgery ...
Andi Xu +30 more
wiley +1 more source
The effects of different prone ventilation strategies on mechanical power and respiratory mechanics in acute respiratory distress syndrome patients: a prospective, single-center observational study. [PDF]
Hong P +5 more
europepmc +1 more source
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han +10 more
wiley +1 more source
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei +10 more
wiley +1 more source
Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma? [PDF]
Kotoulas SC +9 more
europepmc +1 more source

