Brazilian Journal of Medical and Biological Research, 2005 An effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal ...
M.G. Saueressig +5 more
doaj +1 more source
Advanced Science, EarlyView.Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang +13 more
wiley +1 more source
Editorial: The interplay between microbiota and allergen in shaping respiratory mucosa immunity: Role in development of asthma. [PDF]
Front Immunol, 2023 Xia Z, Zhong W, Wu M, Evans SE.
europepmc +1 more source
Rat Nasal Respiratory Mucosa-Derived Ectomesenchymal Stem Cells Differentiate into Schwann-Like Cells Promoting the Differentiation of PC12 Cells and Forming MyelinIn Vitro [PDF]
, 2015 Jian Zhang +4 more
openalex +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
A Novel Preparation Technique for Human Nasal Respiratory Mucosa to Disclose Its Glycosylation Pattern for Bioadhesive Drug Delivery. [PDF]
Pharmaceutics, 2023 Gausterer JC +8 more
europepmc +1 more source
Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells
Advanced Science, EarlyView.ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen +11 more
wiley +1 more source
The compartmentalized upper respiratory mucosa needs time to rally a sufficient immune force for SARS-CoV-2 clearance. [PDF]
Cell Mol Immunol, 2022 Zheng X, Tang X, Li F.
europepmc +1 more source
Advanced Science, EarlyView.A real‐time, high‐definition hyperspectral endoscopy is enabled by developing a spatial‐temporal spectral encoding approach based on low‐frequency stochastic filters combined with an encoding‐guided attention network. It provides hyperspectral image of in vivo tissue with fine superficial features, enables visualization of rapid and subtle ...
Xiaowei Liu +11 more
wiley +1 more source
Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment
Advanced Science, EarlyView.This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang +7 more
wiley +1 more source