ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu +4 more
wiley +1 more source
Intranasal booster drives class switching and homing of memory B cells for mucosal IgA response. [PDF]
Chen S +23 more
europepmc +1 more source
Elexacaftor–Tezacaftor–Ivacaftor Reduces Revision Sinus Surgery in People With Cystic Fibrosis
Elexacaftor–tezacaftor–ivacaftor (ETI) was associated with a significant decrease in the frequency and rate of endoscopic sinus surgeries in patients with cystic fibrosis. These findings suggest an improvement in CF‐related chronic rhinosinusitis outcomes following ETI and may influence future CF treatment decisions.
Amy Lin +6 more
wiley +1 more source
Gastroesophageal reflux-induced cough: the positive feedback loop of microaspiration and neurogenic inflammation. [PDF]
Rui Y +7 more
europepmc +1 more source
Diagnosing Eosinophilic Chronic Rhinosinusitis in Excised Tissue Using Optical Coherence Tomography
This study evaluated whether optical coherence tomography (OCT) can quantify eosinophils in excised sinonasal tissue and diagnose eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). Counts of globules resembling eosinophils on OCT images strongly correlated with eosinophils per HPF on histology, with a cutoff of 45 globules on OCT imaging ...
Ido Badash +6 more
wiley +1 more source
Impact of nonpharmaceutical interventions on inflammatory diseases of the nose. [PDF]
Dai L +7 more
europepmc +1 more source
Orbital Complications of Acute Rhinosinusitis in Adulthood: Predictors of Outcome and Management
In a multicenter cohort of 213 adults with orbital complications of acute rhinosinusitis, 68% required surgery and the modified Chandler classification was the strongest predictor of treatment modality. While abscess‐related and type II complications frequently necessitated surgical management, final ophthalmologic outcomes were uniformly favorable ...
Alessandro Vinciguerra +41 more
wiley +1 more source
Mastoid Surgery Does Not Normalize Tympanometric Middle Ear Pressure in Children With Cholesteatoma
Conflicting mechanism‐based hypotheses have been used to promote selection of different approaches to management of the mastoid in order to optimize middle ear pressure homeostasis after removal of cholesteatoma. For example: (a) conservation of mastoid mucosa and opening of ventilation pathways endoscopically to normalize function, (b) removal of ...
Adrian L. James
wiley +1 more source
Influence of Hypoxia, Dehydration and Salinity on Survival of <i>Orthohalarachne</i> Marine Mite Larvae: Limits to Dispersion. [PDF]
Pérez Zippilli L +4 more
europepmc +1 more source

