Results 61 to 70 of about 1,434,152 (273)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Instructional materials to teach airway reflexes: development of cordel literature and comics

Advances in Physiology Education
The respiratory system encompasses a complex network of neural mechanisms that regulate not only ventilation and gas exchange but also vital protective reflexes such as coughing, sneezing, and swallowing.
Ricardo Murilo Pereira Emídio, Êfeh Victório Monteiro Crempe, Josimary Morais Vasconcelos Oliveira, Roseli Soncini   +3 more
doaj   +1 more source

Recent trends in airway management: we are not ready to give up fiberoptic endoscopy [v1; ref status: indexed, http://f1000r.es/35y]

F1000Research, 2014
The purpose of this correspondence is to discuss recent findings related to current trends in airway management and to discuss the utilization rates of video laryngoscopes versus traditional techniques in USA, UK, and Canada.
Davide Cattano, Rabail Chaudhry, Rashida Callender, Peter Killoran, Carin Hagberg   +4 more
doaj   +1 more source

Paediatrics in Amsterdam

, 2012
The aim of this update is to describe the paediatric highlights from the 2011 European Respiratory Society (ERS) Annual Congress in Amsterdam, the Netherlands.
J. E. Dankert Roelse, Lødrup Carlsen, Karin C, A. Lindblad, Hedlin, G,, G. Hedlin, E. Eber, Turner, Steve W, Dankert-Roelse, JE, MIDULLA, Fabio, Lindblad, A, Dankert-Roelse, Jeannette E, Aurora, Paul, Midulla, F, Turner, SW, Hedlin, Gunilla, Lindblad, Anders,, Eber, E, Ross-Russell, RI, Aurora, P, Eber, Ernst, P. Aurora, K. C. Lødrup Carlsen, S. W. Turner, Carlsen, KCL, R. I. Ross Russell, Ross-Russell, Robert I   +25 more
core   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

End-tidal CO2 responses and ventilatory correlates during voluntary hyperventilation: a repeated-measures pilot study

Frontiers in Physiology
BackgroundControlled voluntary hyperventilation is widely used to study the ventilatory control of end-tidal CO2 (PetCO2), but the breath-by-breath determinants of PetCO2 during an externally paced maneuver remain incompletely characterized.
Liping Wang, Lihao Xue, Fenglin Jia, Huibian Zhang, Lihua Yu, GuiYou Wang, Zhao Gu   +6 more
doaj   +1 more source

Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing

, 2014
The control of breathing is commonly viewed as being a "brainstem affair". As the topic of this special issue of Respiratory Physiology and Neurobiology indicates, we should consider broadening this notion since the act of breathing is also tightly ...
Bretzner, Frederic, Tenorio, Luana, Tenorio, Luana [UNESP], Kinkead, Richard, Gargaglioni, Luciane, Drolet, Guy   +5 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source