Results 41 to 50 of about 826,835 (308)

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Loading of trained inspiratory muscles speeds lactate recovery kinetics [PDF]

open access: yes, 2010
Purpose: To investigate the effects of inspiratory muscle loading (ITL) and inspiratory muscle training (IMT) upon blood lactate concentration ([lacj]B)and acid-base balance following maximal incremental cycling.
Brown, PI, Johnson, MA, Sharpe, GR
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Expert Consensus on the Clinical Application of Oral Small-molecule Antiviral Drugs Against COVID-19

open access: yesInfectious Diseases & Immunity
. Although COVID‑19 no longer constitutes a “public health emergency of international concern”, which still has being spreading around the world at a low level.
Society of Bacterial Infection and Resistance of Chinese Medical Association, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine   +1 more
doaj   +1 more source

Education and expectations for patients with viral upper respiratory infections [PDF]

open access: yes, 2019
Non influenza viral upper respiratory illnesses are responsible for a significant percentage of sick visits to primary care physicians. Patients who expect antibiotics are more likely to be given them, and this contributes to growing antibiotic ...
Thomas, Kathryn
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

THE RESPONSE TO RESPIRATORY RESISTANCE [PDF]

open access: yesJournal of Experimental Medicine, 1927
1. A study has been made of the effects of resistance to respiration in the inspiratory and expiratory phases. 2. Resistance to inspiration caused an increase in respiratory rate, a decrease in tidal air, and in most instances a severe limitation of the minute volume of pulmonary ventilation.
Richmond L. Moore, Carl A. L. Binger
openaire   +1 more source

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]

open access: yes, 2019
Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin   +9 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Antibiotic resistance: Evaluation of levofloxacin treatment in acute respiratory tract infections cases at the Tasikmalaya City Health Center, Indonesia

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2020
Acute respiratory tract infections (ARTIs) are an acute inflammation of the upper and lower respiratory tract caused by the infection of microorganisms or bacteria, viruses, without or accompanied by inflammation of the lung parenchyma.
Danni Ramdhani   +3 more
doaj   +1 more source

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