Results 51 to 60 of about 463,245 (263)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Prevalence and Antimicrobial Resistance Pattern of Serratia marcescens in Respiratory Samples from ICU Patients: A Six Months Prospective Study [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases
Background and study aim:   Serratia marcescens has emerged as a significant nosocomial pathogen in intensive care units (ICUs), particularly causing ventilator-associated pneumonia and respiratory tract infections.
Sheetal Goenka, Wanshisha Wanswett, Shivani Tyagi, Poonam Loomba, Manisha Jain, Abha Sharma   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Antibiotic Resistance in Oral/Respiratory Bacteria [PDF]

Critical Reviews in Oral Biology & Medicine, 1998
In the last 20 years, changes in world technology have occurred which have allowed for the rapid transport of people, food, and goods. Unfortunately, antibiotic residues and antibiotic-resistant bacteria have been transported as well. Over the past 20 years, the rise in antibiotic-resistant gene carriage in virtually every species of bacteria, not ...
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

COVID-19 Therapeutics Use by Social Deprivation Index in England, July 2020–April 2023

COVID
Coronavirus disease-19 (COVID-19) has disproportionately affected certain demographics in England, exacerbating existing health disparities. Effective therapeutics are a critical line of defence against COVID-19, particularly for patients at elevated ...
Angela Falola, Hanna Squire, Sabine Bou-Antoun, Alessandra Løchen, Colin S. Brown, Alicia Demirjian   +5 more
doaj   +1 more source

Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis

ERJ Open Research, 2020
Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects disease severity.
Yuji Yamamoto, Keisuke Miki, Kazuyuki Tsujino, Tomoki Kuge, Fukuko Okabe, Takahiro Kawasaki, Takanori Matsuki, Hiroyuki Kagawa, Mari Miki, Hiroshi Kida   +9 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Monitoring of resistance of bacterial microflora to antibacterial drugs in children with acute respiratory infections

Aktualʹnaâ Infektologiâ, 2018
The article describes the problem of antibiotic resistance of main bacterial pathogens in children with acute respiratory diseases, mechanisms of occurrence and ways to overcome them.
Kh.V. Melnyk, G.B. Mateyko
doaj   +1 more source

Claustrum Involvement in New Onset Refractory Status Epilepticus: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The claustrum sign is a distinctive neuroimaging finding characterized by bilateral T2/FLAIR hyperintensity of the claustrum, one of the most interconnected regions of the human brain. It was first described in new‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES).
Margherita Burani, Lorenzo Muccioli, Giada Giovannini, Niccolò Orlandi, Francesca Bisulli, Stefano Meletti   +5 more
wiley   +1 more source