Results 61 to 70 of about 96,357 (264)

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Mucin‐Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity

Advanced Science, EarlyView.
Virucidal polymers serve as effective antivirals by not only inhibiting viruses but also destroying them. Inspired by the chemical properties of mucin‐mimetics, dendronized polyglycerol‐sulfated, mucin‐inspired amphiphilic copolymers (MIACPs) have been developed.
Raju Bej, Enyu Xie, Kai Ludwig, Robert F. Schmidt, Yannic Kerkhoff, Robert Dalgliesh, Nilanjan Paul, Michael Gradzielski, Andreas Herrmann, Christian Sieben, Rainer Haag   +10 more
wiley   +1 more source

Respiratory Syncytial Virus Infection in Cattle [PDF]

Veterinary Pathology, 2013
Bovine respiratory syncytial virus (RSV) is a cause of respiratory disease in cattle worldwide. It has an integral role in enzootic pneumonia in young dairy calves and summer pneumonia in nursing beef calves. Furthermore, bovine RSV infection can predispose calves to secondary bacterial infection by organisms such as Mannheimia haemolytica ...
Sacco, R., McGill, J., Ackermann, Mark, Pillatzki, A., Palmer, M., Ackermann, M.   +5 more
openaire   +3 more sources

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

The Lancet Global Health, 2019
Summary: Background: Influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus are the most common viruses associated with acute lower respiratory infections in young children (
You Li, MSc, Rachel M Reeves, PhD, Xin Wang, MSc, Quique Bassat, ProfMD, W Abdullah Brooks, MD, Cheryl Cohen, PhD, David P Moore, PhD, Marta Nunes, PhD, Barbara Rath, ProfPhD, Harry Campbell, ProfMD, Harish Nair, ProfPhD, Sozinho Acacio, Wladimir J Alonso, Martin Antonio, Guadalupe Ayora Talavera, Darmaa Badarch, Vicky L Baillie, Gisela Barrera-Badillo, Godfrey Bigogo, Shobha Broor, Dana Bruden, Philippe Buchy, Peter Byass, James Chipeta, Wilfrido Clara, Duc-Anh Dang, Carla Cecília de Freitas Lázaro Emediato, Menno de Jong, José Alberto Díaz-Quiñonez, Lien Anh Ha Do, Rodrigo A Fasce, Luzhao Feng, Mark J Ferson, Angela Gentile, Bradford D Gessner, Doli Goswami, Sophie Goyet, Carlos G Grijalva, Natasha Halasa, Orienka Hellferscee, Danielle Hessong, Nusrat Homaira, Jorge Jara, Kathleen Kahn, Najwa Khuri-Bulos, Karen L Kotloff, Claudio F Lanata, Olga Lopez, Maria Renee Lopez Bolaños, Marilla G Lucero, Florencia Lucion, Socorro P Lupisan, Shabir A Madhi, Omphile Mekgoe, Cinta Moraleda, Jocelyn Moyes, Kim Mulholland, Patrick K Munywoki, Fathima Naby, Thanh Hung Nguyen, Mark P Nicol, D James Nokes, Daniel E Noyola, Daisuke Onozuka, Nandhini Palani, Yong Poovorawan, Mustafizur Rahman, Kaat Ramaekers, Candice Romero, Elizabeth P Schlaudecker, Brunhilde Schweiger, Phil Seidenberg, Eric A F Simoes, Rosalyn Singleton, Sujatha Sistla, Katharine Sturm-Ramirez, Nungruthai Suntronwong, Agustinus Sutanto, Milagritos D Tapia, Somsak Thamthitiwat, Ilada Thongpan, Gayani Tillekeratne, Yeny O Tinoco, Florette K Treurnicht, Claudia Turner, Paul Turner, Rogier van Doorn, Marc Van Ranst, Benoit Visseaux, Sunthareeya Waicharoen, Jianwei Wang, Lay-Myint Yoshida, Heather J Zar   +92 more
doaj   +1 more source

Corticosteroids for the common cold [PDF]

, 2015
BACKGROUND: The common cold is a frequent illness, which, although benign and self limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit.
Del Mar, Chris B., Glasziou, Paul P., Hayward, Gail, Heneghan, Carl J., Perera, Rafael, Thompson, Matthew J.   +5 more
core   +1 more source

Respiratory syncytial virus infection and immunity [PDF]

Reviews in Medical Virology, 2012
SUMMARYRespiratory syncytial virus (RSV) is the leading cause for childhood hospitalization and respiratory distress, being recognized as a major health and economic burden worldwide. RSV can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination.
Gonzalez, Pablo A., Bueno, Susan M., Carreno, Leandro J., Riedel, Claudia A., Kalergis, Alexis M.   +4 more
openaire   +16 more sources

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Immunization during pregnancy

Expert Review of Vaccines, 2018
Introduction: Vaccination in pregnancy has been shown to be effective for the prevention of influenza and pertussis in infants, providing support for similar strategies to prevent group B streptococcus and respiratory syncytial virus infections that ...
Paul Loubet, Olivia Anselem, Odile Launay   +2 more
doaj   +1 more source

Incidence of respiratory viruses in peruvian children with acute respiratory infections [PDF]

, 2015
Acute respiratory infections are responsible for high morbi-mortality in Peruvian children. However, the etiological agents are poorly identified. This study, conducted during the pandemic outbreak of H1N1 influenza in 2009, aims to determine the main ...
Albuquerque, Alonso, Ampuero, Barenfanger, Bellau-Pujol, Budge, Budge, Casas, Coiras, Coiras, Forshey, Freymuth, Garcia, Gerna, Gomez, Grassi, Gómez, Kwon, Lamarão, Luchsinger, Mahony, Munayco, Nasreen, Padilla-Ygreda, Ren, Salmón-Mulanovich, Scheltinga, Schoub, Sovero, Turner, Van de Pol, van Elden, van Woensel, Vidaurreta, Villaran, Watanabe, Zhao   +36 more
core   +4 more sources