Results 141 to 150 of about 1,029,493 (234)

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Cepheid Xpert^® Flu/RSV and Seegene Allplex^™ RP1 show high diagnostic agreement for the detection of influenza A/B and respiratory syncytial viruses in clinical practice. [PDF]

Influenza Other Respir Viruses, 2021
Wabe N, Lindeman R, Post JJ, Rawlinson W, Miao M, Westbrook JI, Georgiou A.   +6 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Volatile Relay Biosensing and Mobile Phone Imaging for Detection of Influenza Virus

Advanced Functional Materials, Volume 36, Issue 74, 14 September 2026.
Detection of volatile organic compounds is performed via a coupled enzymatic assay with mobile phone detection of the signal. Specific application demonstrated herein is the detection of influenza virus, across multiple levels of biological complexity, up to patient‐derived samples.
Dante G. Andersen, Josefine H. Jakobsen, Mikkel Høj Nielsen, Shreyans Chatterjee, Detlef Michel, Jan Münch, Rüdiger Gross, Alexander N. Zelikin   +7 more
wiley   +1 more source

The Baboon as a Model to Study Human Health and Complex Disease

American Journal of Primatology, Volume 88, Issue 9, September 2026.
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley   +1 more source

Do amyloid trajectories reach a ceiling? Evidence from iterative approximation and simulation

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Qualitative models of Alzheimer's disease (AD) pathology often posit that amyloid accumulation follows a sigmoid curve, indicating that the rate of deposition wanes over time. Longitudinal positron emission tomography (PET) data now allow us to investigate amyloid accumulation trajectories with greater detail and over longer ...
Jason R. Gantenberg, Renaud La Joie, Margo B. Heston, Sarah F. Ackley, for the Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

Qianjinweijingtang Decoction and Its Granule Inhibit Respiratory Syncytial Virus Infection and the Associated Inflammatory Response

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The classical herbal formula Qianjinweijingtang in both decoction and granule forms, exhibits anti‐RSV activity. Isoliquiritigenin, quercetin, and gallic acid are identified as key active compounds. The mechanism involves interfering with viral entry and downregulating HIF‐1α and inflammatory responses, positioning the granule formulation as a ...
Chu‐Yi Liao, Mei‐Lan Yang, Ze‐Ping Chen, Bin Chen, Yu‐Jun Tang, Zhen Wang, Hui‐Nan Zhao, Su‐Hua Deng, Jin‐Hai Ye, Zhong Liu, Li‐Feng Chen, Man‐Mei Li   +11 more
wiley   +1 more source

Role of Respiratory Viruses in Severe Acute Respiratory Failure

Respiratory viruses are widespread in the community, affecting both the upper and lower respiratory tract. This review provides an updated synthesis of the epidemiology, pathophysiology, clinical impact, and management of severe respiratory viral ...
Mokrani, David, Timsit, Jean-François, Jean-François Timsit, David Mokrani   +3 more
core   +1 more source

Preparation and Infection of Bovine Precision‐Cut Lung Slices (b‐PCLS) as an Ex Vivo Model for Respiratory Pathogens

Current Protocols, Volume 6, Issue 9, September 2026.
Abstract Precision‐cut lung slices (PCLS) represent a physiologically relevant ex vivo model that bridges the gap between simplified in vitro systems and in vivo animal studies by preserving native lung architecture, cellular diversity, and functional responses.
Asal Ahmadi, Ghazal Ahmadi, Vilde Galleberg‐Wahlberg, Abdolrahman Khezri, Veslemøy Sunniva Oma, Jochen Meens, Mette Myrmel, Ann‐Katrin Llarena   +7 more
wiley   +1 more source

Coxsackievirus B Infections Are Associated With the Risk of Islet Autoimmunity in Children With Strong Genetic Susceptibility to Type 1 Diabetes—Results From the TRIGR Divia Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Aims Especially, the coxsackievirus B group of enteroviruses has been linked to the development of islet autoimmunity and type 1 diabetes in genetically susceptible individuals. Our aim was to study the possible associations of 10 different microbial infections with islet autoimmunity in a large international prospective study.
Maarit Oikarinen, Amirbabak Sioofy‐Khojine, Leena Puustinen, David Cuthbertson, Jussi Lehtonen, Niila V. V. Jouppila, Johnny Ludvigsson, Leena Hakola, Sari Niinistö, Iris Erlund, Mikael Knip, Jeffrey P. Krischer, Suvi M. Virtanen, Heikki Hyöty, on behalf of the TRIGR Investigators   +14 more
wiley   +1 more source