Results 141 to 150 of about 28,018,362 (350)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji +13 more
wiley +1 more source
Prevalence of microorganisms responsible for respiratory tract infections, Babol, 1997
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2000 Objective: There is no doubt that causes of respiratory tract infections in ICU are very important. These organisms are one of the most important causes of mortality in ICU. Methods: In this cross-sectional study performed on all patients admitted in ICU
Kh Bidjani, K Aghchelli, M Arshi
doaj
Studies of the Effects of Acceleration on Cardiovascular and Respiratory Dynamics Semiannual Status Report, Apr. 1 - Oct. 1, 1966 [PDF]
On-line time sharing data processing and computer analysis techniques, and acceleration effects on cardiovascular and respiratory ...
Wood, E. H.
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Modeling of Respiratory System [PDF]
, 2008 Tato práce se zabývá simulací dýchací soustavy. Cílem studie je porozumění dýchací soustavy lidského organismu, společně s volbou vhodných algoritmů a jejich následnou implementací do matematického modelu.
Matoušek, Josef
core
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Toxicology of the respiratory system
Folia Pharmacologica Japonica, 2009 呼吸器は，空気から酸素を取り入れ血液から二酸化炭素を放出するガス交換を行うための器官である．空気中に存在す化学物質は呼吸を通して体内に入るため，呼吸器はこれらの化学物質に最初に接触しその影響を最も受けやすい器官である．このため，大気汚染物質による健康障害では呼吸器が標的器官となることが多い．医薬品の分野では，吸入以外の経路でも抗癌剤等による薬剤性肺障害の報告があり，本誌でも詳しい総説がある（1）．また，近年は経鼻投与など経気道的に投与する薬剤の実用化が進んでおり，医薬品の開発に際して鼻腔などの気道を含む呼吸器への直接的な接触による副作用が課題になってきている．本稿では，鼻腔等の気道を中心として，呼吸器の構造と機能，呼吸器毒性の検査法，薬剤等による呼吸器毒性について概説する．
openaire +3 more sources