Results 21 to 30 of about 2,022,629 (285)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Age-related changes in the respiratory system [PDF]

, 1999
This article summarises the main structural and physiological changes which take place in the lung from young adulthood to senescence. An understanding of these changes helps the clinician to correctly interpret some results of radiology and pulmonary ...
Ebejer, Martin J., Lesauskaite, Vita
core  

The incidence and clinical burden of respiratory syncytial virus disease identified through hospital outpatient presentations in Kenyan children [PDF]

, 2012
There is little information that describe the burden of respiratory syncytial virus (RSV) associated disease in the tropical African outpatient setting. Methods We studied a systematic sample of children aged
Ann Bett, Benjamin J. Cowling, BG Williams, BJ Selwyn, CB Hall, D. James Nokes, DJ Nokes, DJ Nokes, DJ Nokes, EA Okiro, EA Okiro, EA Okiro, Emelda A. Okiro, F Freymuth, F Henderson, FE Moura, I Rudan, J Bryce, JAG Scott, K Mulholland, MK Mwaniki, MP Loscertales, MP Loscertales, MW Weber, MW Weber, MW Weber, Mwanajuma Ngama, PD Scott, PD Scott, PD Scott, R Ochola, RG Fisher, SA Madhi, SE Robertson, TW Mwangi, W Glezen   +35 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Respiratory Syncytial Virus During the COVID-19 Pandemic Compared to Historic Levels: A Retrospective Cohort Study of a Health System [PDF]

, 2022
Naimisha Movva, Mina Suh, Heidi Reichert, Bradley J. Hintze, Mark Sendak, Zachary Wolf, Shannon Carr, Tom Kaminski, Meghan White, Kimberley A. Fisher, Charles T. Wood, Jon P. Fryzek, Christopher B. Nelson, William Malcolm   +13 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)—trial protocol [PDF]

, 2022
Brijesh Patel, Sharon Mumby, Nicholas Johnson, Emanuela Falaschetti, Jorgen Hansen, Ian M. Adcock, Daniel F. McAuley, Masao Takata, Dan Stieper Karbing, Matthieu Jabaudon, Peter Schellengowski, Stephen Edward Rees, on behalf of the DeVENT study group   +12 more
openalex   +1 more source

Prevalence of respiratory pathogens in nasal swabs from horses with acute respiratory disease in Belgium [PDF]

, 2016
Contagious respiratory infections are an important cause of respiratory disease in horses, resulting in impaired pulmonary function, poor performance and sometimes severe illness.
Amory, H, Broux, Barbara, Deprez, Piet, Frippiat, T, Gasthuys, Frank, Gryspeerdt, Annick, Legrand, L, Pardon, Bart   +7 more
core  

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]

, 2013
BACKGROUND: Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV ...
Abadi A, Amy K Reeve, Brierley EJ, Broadwater L, Campbell GR, Campbell GR, Campbell GR, Campbell GR, Don J Mahad, Doug M Turnbull, Dutta R, Dutta R, Graham R Campbell, Harding AE, Horvath R, Iryna Ziabreva, Johnson MA, Krishnan KJ, Kumleh HH, Larsson NG, Mahler A, McFarland R, Murphy JL, Nociti V, Palace J, Parise G, Patte M, Rahman S, Rahman S, Reeve AK, Richard Reynolds, Sakiyama Y, Taylor RW, Verny C, Witte ME, Witte ME, Yu-Wai-Man P   +36 more
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source