Results 41 to 50 of about 1,188,991 (293)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mapping the intersection of demographics, behavior, and government response to the COVID-19 pandemic: an observational cohort study

BMC Global and Public Health
Background During the early phase of the COVID-19 pandemic, the province of Ontario enacted restrictions and recommendations that changed over time. These measures were effective in reducing COVID-19-related illness and deaths, but adherence to these non-
Katherine M. Kennedy, Erica N. DeJong, Alexander W.Y. Chan, Allison E. Kennedy, Alainna Jamal, Michael G. Surette, Maggie J. Larché, Mark Larché, Nathan Hambly, Kjetil Ask, Stephanie A. Atkinson, Paul D. McNicholas, Allison McGeer, Brenda L. Coleman, Dawn M.E Bowdish   +14 more
doaj   +1 more source

Clinical characteristics of amyloidosis with isolated respiratory system involvement: A review of 13 cases

Annals of Thoracic Medicine, 2012
Background: Isolated pulmonary amyloidosis is a very rare disease. Methods: We retrospectively reviewed the records of patients with pathologically proven isolated pulmonary amyloidosis treated at our hospital from 1990 to 2011. Results: There were 9
Haiqing Chu, Lan Zhao, Zhemin Zhang, Tao Gui, Xianghua Yi, Xiwen Sun   +5 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Reparação traqueal em cães: transplante autógeno vs implante homógeno conservado em glicerina a 98% de cartilagem da pina Tracheal healing in dogs: autograft versus homograft implant preserved in 98% glycerin of pinna cartilage

Ciência Rural, 2001
Diversas patologias acometem a traquéia dos animais domésticos de forma a comprometer o fluxo respiratório, inclusive a sobrevivência do animal. Obstrução por corpo estranho ou neoplasias, rupturas traumáticas, colapso e estenose são tidas como as ...
Emerson Antonio Contesini, Mônica Seabra Salles, João Antônio Tadeu Pigatto, Ney Luis Pippi, Alceu Gaspar Raiser   +4 more
doaj   +1 more source

RESPIRATORY SYSTEM [PDF]

Archives of Pediatrics & Adolescent Medicine, 1912
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openaire   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source