Results 91 to 100 of about 21,337,282 (283)

Normality ranges of urine oxidative stress markers (8-OHdG and isoprostane) in Italian people free from respiratory diseases-Preliminary results [PDF]

, 2012
BACKGROUND: The study of oxidative stress (OxS) is becoming increasingly important in respiratory disease research. To our knowledge, the reference ranges of urinary 8-hydroxy-deoxy-guanosine (8-OHdG) and 8-isoprostane (isoprostane), a DNA and a lipid ...
de Marco Roberto, Degan Paolo, Pesce Giancarlo, Nicolis Morena, Zanolin M Elisabetta, Jalil Aneza, Girardi Paolo   +6 more
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Nosospecific features of redox processes in bronchial asthma and chronic obstructive pulmonary disease

Zdorovʹe Rebenka, 2017
The literature review presents current data on the specific features of oxidative stress, the functional activity of the antioxidant system and development of the inflammatory process in bronchial asthma and chronic obstructive pulmonary disease.
О.E. Abaturov, О.P. Volosovets, T.P. Borysova   +2 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Construction and Validation of an Automatic Segmentation Method for Respiratory Sound Time Labels

The Clinical Respiratory Journal
Background In the field of respiratory system diseases, the utilization of respiratory sounds in auscultation plays a crucial role in the specific disease diagnosis.
Jian Fan, Haoran Ni, Xiulan Chen, Yulin Duan, Wanmin Wang, Fan Xu, Yan Shang   +6 more
doaj   +1 more source

Role of the mechanisms of the antioxidant system in the development of respiratory diseases

Zdorovʹe Rebenka, 2017
The review of the literature presents current data on the role of NOX proteins in the physiology of the lungs and in the development of respiratory diseases.
A.E. Abaturov, A.P. Volosovets, T.P. Borysova   +2 more
doaj   +1 more source

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure [PDF]

, 2008
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear.
Julian Thompson, Nicholas S Hopkinson, Anthony Kehoe, Hopkinson, NS, Humphries, SE, Mostafa Ghanei, Montgomery Hugh, Khoshbaten, A, Hopkinson Nicholas S, Soroush, MR, Hugh Montgomery, Thompson Julian, Hosseini-Khalili, AR, Steve E Humphries, Kehoe, A, Montgomery, H, Ghanei, M, Kehoe Anthony, Hosseini-khalili Ali, Khoshbaten A, A Khoshbaten, Mohammad Reza Soroush, Soroush Mohammad, Thompson, J, Humphries Steve E, Ghanei Mostafa, Ali Reza Hosseini-khalili   +26 more
core   +2 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Acute respiratory diseases: progression features, pharmaceutical therapy

Медицинский совет, 2018
Acute respiratory diseases (ARD) are widespread diseases and are of great social importance. Diagnosis of acute respiratory infections implies the damage to the respiratory system caused by a wide range of pathogens.
N. V. Orlova, T. G. Suranova
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source