Enhancing TB Vaccine Efficacy: Current Progress on Vaccines, Adjuvants and Immunization Strategies
Vaccines, 2023 Tuberculosis (TB) remains a global infectious disease primarily transmitted via respiratory tract infection. Presently, vaccination stands as the primary method for TB prevention, predominantly reliant on the Bacillus Calmette–Guérin (BCG) vaccine ...
Hui Wang +6 more
doaj +1 more source
Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome
medRxiv, 2021 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the respiratory tract, results in highly variable outcomes ranging from minimal illness to death, but the reasons for this are not well understood.
Carter Merenstein +20 more
semanticscholar +1 more source
Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge
Frontiers in Immunology, 2021 Evidence supports a role of complement anaphylatoxin C5a in the pathophysiology of COVID-19. However, information about the evolution and impact of C5a levels after hospital discharge is lacking. We analyzed the association between circulating C5a levels
Yaiza Senent +35 more
doaj +1 more source
European Respiratory Journal, 2022 Background Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking.
E. V. van Meel +68 more
semanticscholar +1 more source
Advanced NanoBiomed Research, 2021 Air-liquid interface (ALI) culture models currently represent a valid instrument to recreate the typical aspects of the respiratory tract in vitro in both healthy and diseased state.
Domizia Baldassi +2 more
semanticscholar +1 more source
Elevated microRNA-21 Is a Brake of Inflammation Involved in the Development of Nasal Polyps
Frontiers in Immunology, 2021 BackgroundCRSwNP is an inflammatory disease but the mechanism is not yet fully understood. MiR-21, a member of miRNAs, has been reported to play roles in mediating inflammation.
Ruowu Liu +11 more
doaj +1 more source
The Diagnostic Value of Metagenomic Next–Generation Sequencing in Lower Respiratory Tract Infection
Frontiers in Cellular and Infection Microbiology, 2021 Lower respiratory tract infections are associated with high morbidity and mortality and significant clinical harm. Due to the limited ability of traditional pathogen detection methods, anti-infective therapy is mostly empirical.
Yan Zheng, X. Qiu, Ting Wang, Jie Zhang
semanticscholar +1 more source
An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]
, 2020 beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip +8 more
core +2 more sources
Serum β2-microglobulin may be a viral biomarker by analyzing children with upper respiratory tract infections and exanthem subitum: a retrospective study [PDF]
PeerJ, 2021 Background Due to the lack of effective and feasible viral biomarkers to distinguish viral infection from bacterial infection, children often receive unnecessary antibiotic treatment.
Xulong Cai +4 more
doaj +2 more sources
Bronchiolitis – It Is Time for a Unique Definition [PDF]
, 2016 Bronchiolitis is the most common lower respiratory tract infections in infants. It is time to reach a unique clinical definition, encompassing the acute onset of respiratory distress with cough, tachypnoea, retraction and
Midulla, Fabio, Nenna, Raffaella
core +1 more source