Results 101 to 110 of about 882,034 (305)

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielman, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

The respiratory tract in pigs and its immune system: a review

Veterinární Medicína, 2013
The growing amount of information regarding mucosal immunology in animals resulted from a need to better understand the pathogenesis of diseases entering the body through mucosa surfaces, including the respiratory tract.
J. Krejci, K. Nechvatalova, M. Blahutkova, M. Faldyna   +3 more
doaj   +1 more source

Chemical exposure-response relationship between air pollutants and reactive oxygen species in the human respiratory tract

Scientific Reports, 2016
Air pollution can cause oxidative stress and adverse health effects such as asthma and other respiratory diseases, but the underlying chemical processes are not well characterized.
P. Lakey, T. Berkemeier, Haijie Tong, Andrea M. Arangio, Kurt Lucas, U. Pöschl, M. Shiraiwa   +6 more
semanticscholar   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Frequent detection of bocavirus DNA in German children with respiratory tract infections

BMC Infectious Diseases, 2006
Background In a substantial proportion of respiratory tract diseases of suspected infectious origin, the etiology is unknown. Some of these cases may be caused by the recently described human bocavirus (hBoV). The aim of this study was to investigate the
Blath Katharina, Tollmann Franz, Schubert Jörg, Neske Florian, Weissbrich Benedikt, Blessing Kerstin, Kreth Hans   +6 more
doaj   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

Advanced Science, EarlyView.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu, Chengya Huang, Xin Li, Haonan Yu, Yuefeng Xia, Kun Liu, Xingji You, Jingxiang Wu   +7 more
wiley   +1 more source

THE EFFECTS OF AIR POLLUTION OF DISEASES OТ THE RESPIRATORY ORGANS FOR CHILDREN AND ADOLESCENTS

Медицинский вестник Юга России, 2017
Objective: to assess the impact of air pollutants on respiratory tract diseases in children and adolescents of industrial region.Materials and methods: the study of respiratory tract diseases and their prevalence for children 0-14 and adolescents 15-17 ...
S. V. Карrаnоv, I. V. Koktyshev
doaj   +1 more source

The upper respiratory tract microbiome and its potential role in bovine respiratory disease and otitis media

Scientific Reports, 2016
The upper respiratory tract (URT) hosts a complex microbial community of commensal microorganisms and potential pathogens. Analyzing the composition and nature of the healthy URT microbiota and how it changes over time will contribute to a better ...
S. Lima, A. Teixeira, C. H. Higgins, F. Lima, R. Bicalho   +4 more
semanticscholar   +1 more source