Results 141 to 150 of about 910,981 (387)

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv   +12 more
wiley   +1 more source

Do children’s upper respiratory tract infections benefit from probiotics?

open access: yesBMC Infectious Diseases, 2014
BackgroundThe microbiota of the gastrointestinal tract have profound influence at multiple levels, even on the development and maintenance of lung immunity and inflammation.
S. Esposito, D. Rigante, N. Principi
semanticscholar   +1 more source

Prevalence and Outpatient Clinical Diagnostic Approaches for Common Acute Respiratory Tract Infections in Children Under Five Years of Age: A Cross-Sectional Study

open access: yesPediatric Health, Medicine and Therapeutics
Munanura Turyasiima,1,2 Gloria Kiconco,1,3 Walufu Ivan Egesa,4 Sabinah Twesigemukama,1 Martin Nduwimana1 1Department of Pediatrics and Child Health, Kampala International University, Kampala, Uganda; 2Department of Standards Compliance Accreditation and ...
Turyasiima M   +4 more
doaj  

Analysis of the incidence of influenza and acute upper respiratory tract infections under conditions of routine influenza vaccination

open access: yesActa Biomedica Scientifica
Background. Acute upper respiratory tract infections and influenza, while maintaining high epidemiological, social and economic significance, have a major effect on the public health of countries and individual regions.The aim.
T. A. Bayanova   +3 more
doaj   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

open access: yesAnnals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel   +10 more
wiley   +1 more source

Performance of diagnostic tests to detect respiratory viruses in older adults. [PDF]

open access: yes, 2010
The performance of 4 laboratory methods for diagnosis of viral respiratory tract infections (RTI) in older adults was evaluated. Seventy-four nasopharyngeal (NP) swab specimens were obtained from 60 patients with RTI at a long-term care facility over 2 ...
Caram, Lauren B   +7 more
core  

Epidemiology of Lower Respiratory Tract Infections

open access: yesJournal of Chemotherapy, 1995
The aim of this review is to focus on the epidemiology of lower respiratory tract infections, the etiology, prognosis and risk factors, dividing these problems into the following issues: global impact of these afflictions, community-acquired pneumonia, hospital acquired pneumonia, respiratory infections in surgery, acute bronchitis and exacerbations of
BARIFFI F   +2 more
openaire   +4 more sources

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