Results 141 to 150 of about 588,190 (267)

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Swiss community-based surveillance of respiratory virus co-occurrence in 2022-2024. [PDF]

Microbiol Spectr
Pérez-Rodríguez FJ, Goncalves Cabecinhas AR, Suter-Boquete P, Spedaliero T, Hulo N, Kaiser L, Eckerle I, Essaidi-Laziosi M.   +7 more
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

Respiratory virus genomic epidemiology during post-pandemic re-emergence of influenza in Australia. [PDF]

Virus Evol
Rockett RJ, Agius JE, Chandra S, Fong W, Aziz A, Suster CJE, Basile K, Lam C, Chen SC, Dwyer DE, Kok J, Sullivan SG, Barr IG, Sintchenko V, Golubchik T.   +14 more
europepmc   +1 more source

Transport–Reaction–Signal Coupling in Lateral Flow Assays for Next‐Generation Point‐of‐Care Diagnostics

Advanced Science, EarlyView.
Lateral flow assays are evolving into interdisciplinary, system‐level sensing platforms. Recent innovations are deconstructed through coupled phases of mass transfer, reaction, and signal transduction, revealing interdependence across porous materials, interfacial chemistry, nanolabels, readout devices, and data‐enabled analysis.
Yan Pan, Yuewei Li, Chao Mi, Zhengwen Yang, Lana McClements, Steven J. Langford, Jiayan Liao   +6 more
wiley   +1 more source

Respiratory virus immune response in the aged host. [PDF]

Immun Ageing
Parks OB, Kalavacharla A, Williams JV.
europepmc   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Impact of healthcare-associated respiratory virus infections in children. [PDF]

Infect Prev Pract
Miyashita A, Shibata M, Funakoshi H, Nakamura K, Miyokawa S, Horikoshi Y.   +5 more
europepmc   +1 more source

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

Air conditioning, ventilation, and respiratory virus transmission potential in South India. [PDF]

Int J Infect Dis
Shah P, Pischel L, Sack B, Abdul Basith KM, Dauphinais MR, Jain K, Martins MF, Wallace S, Karoly M, Lakshminarayanan S, Cintron C, Subramanian S, Sahay A, Koura KG, Brooks R, Shenoi S, Chinnakali P, Sinha P.   +17 more
europepmc   +1 more source