Results 51 to 60 of about 569,278 (268)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Mixed Respiratory Virus Infections

Journal of Clinical Virology, 2008
Mixed respiratory viral infections are double negative common and evidence that they are associated with severe disease is supported by some groups. This controversial observation can be explained by the lack of sensitivity of the assessed methods used for viral identification and by the small number of patients included in the randomized cohorts ...
Paranhos-Baccalà, Gláucia, Komurian-Pradel, Florence, Richard, Nathalie, Vernet, Guy, Lina, Bruno, Floret, Daniel   +5 more
openaire   +2 more sources

A comparative assessment of adult mosquito trapping methods to estimate spatial patterns of abundance and community composition in southern Africa

Parasites & Vectors, 2019
Background Assessing adult mosquito populations is an important component of disease surveillance programs and ecosystem health assessments. Inference from adult trapping datasets involves comparing populations across space and time, but comparisons ...
Erin E. Gorsich, Brianna R. Beechler, Peter M. van Bodegom, Danny Govender, Milehna M. Guarido, Marietjie Venter, Maarten Schrama   +6 more
doaj   +1 more source

Virus particle propagation and infectivity along the respiratory tract and a case study for SARS-CoV-2

Scientific Reports, 2022
Respiratory viruses including Respiratory Syncytial Virus, influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause serious and sometimes fatal disease in thousands of people annually.
Dixon Vimalajeewa, Sasitharan Balasubramaniam, Donagh P. Berry, Gerald Barry   +3 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Respiratory syncytial virus and other respiratory viruses

The Pediatric Infectious Disease Journal, 2003
Respiratory syncytial virus (RSV), a nonsegmented, single stranded RNA virus, infects one-half of all infants within the first year of life. RSV possesses pathogenetic qualities that may be attributed to the interplay of viral and host-specific factors including virus strains of different virulence, size of the inoculum, family history of asthma or ...
openaire   +3 more sources

Immunogenicity of intranasal vaccine based on SARS-CoV-2 spike protein during primary and booster immunizations in mice

Human Vaccines & Immunotherapeutics
Mucosal immunity plays a crucial role in combating and controlling the spread of highly mutated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Huijie Yang, Ying Xie, Shuyan Li, Chunting Bao, Jiahao Wang, Changgui Li, Jiaojiao Nie, Yaru Quan   +7 more
doaj   +1 more source

Assessment of baseline age-specific antibody prevalence and incidence of infection to novel influenza A/H1N1 2009

Health Technology Assessment, 2010
Objectives: The objectives of the H1N1 2009 serological surveillance project were twofold: to document (1) the prevalence of cross-reactive antibodies to H1N1 2009 by age group in the population of England prior to arrival of the pandemic strain virus in
P Hardelid, NJ Andrews, K Hoschler, E Stanford, M Baguelin, PA Waight, M Zambon, E Miller   +7 more
doaj   +1 more source

Influenza virus respiratory infection and transmission following ocular inoculation in ferrets. [PDF]

PLoS Pathogens, 2012
While influenza viruses are a common respiratory pathogen, sporadic reports of conjunctivitis following human infection demonstrates the ability of this virus to cause disease outside of the respiratory tract.
Jessica A Belser, Kortney M Gustin, Taronna R Maines, Mary J Pantin-Jackwood, Jacqueline M Katz, Terrence M Tumpey   +5 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source