Results 51 to 60 of about 588,190 (267)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Enabling genomic surveillance from 30 years of linked English sentinel network data: The Wellcome Quinquagenarian (QQG) Biomedical Resource [version 1; peer review: 2 approved]

Wellcome Open Research
Background The World Health Organisation recommends integrating viral genome sequences and sentinel surveillance data. We report progress in linking clinical, virology, and sequence data to enable genomic surveillance of influenza, respiratory syncytial ...
Cecilia Okusi, Omid Parvizi, Shuma Banik, Mark Joy, Beatrix Kele, Katja Hoschler, Joanna Ellis, Angie Lackenby, Conall Watson, Richard Pebody, Maria Zambon, Fatima Batool, Jamie Lopez Bernal, Praveen SebastianPillai, Simon de Lusignan   +14 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Respiratory syncytial virus infection, non‐respiratory syncytial virus respiratory infections, and later wheezing

Pediatrics International
Abstract Background Studies investigating whether respiratory syncytial virus (RSV) infection, non‐RSV respiratory infections, respiratory‐related disorders, and non‐respiratory‐related disorders are associated with subsequent wheezing are limited in Japan.
Ippei Takahashi, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Yoshikazu Nakayama, Atsushi Momose, Naho Tsuchiya, Satoshi Nagaie, Soichi Ogishima, Gen Tamiya, Nobuo Fuse, Atsushi Hozawa, Junichi Sugawara, Shigeo Kure, Shinichi Kuriyama   +18 more
openaire   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Immunogenicity of intranasal vaccine based on SARS-CoV-2 spike protein during primary and booster immunizations in mice

Human Vaccines & Immunotherapeutics
Mucosal immunity plays a crucial role in combating and controlling the spread of highly mutated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Huijie Yang, Ying Xie, Shuyan Li, Chunting Bao, Jiahao Wang, Changgui Li, Jiaojiao Nie, Yaru Quan   +7 more
doaj   +1 more source

Assessment of baseline age-specific antibody prevalence and incidence of infection to novel influenza A/H1N1 2009

Health Technology Assessment, 2010
Objectives: The objectives of the H1N1 2009 serological surveillance project were twofold: to document (1) the prevalence of cross-reactive antibodies to H1N1 2009 by age group in the population of England prior to arrival of the pandemic strain virus in
P Hardelid, NJ Andrews, K Hoschler, E Stanford, M Baguelin, PA Waight, M Zambon, E Miller   +7 more
doaj   +1 more source

A comparative assessment of adult mosquito trapping methods to estimate spatial patterns of abundance and community composition in southern Africa

Parasites & Vectors, 2019
Background Assessing adult mosquito populations is an important component of disease surveillance programs and ecosystem health assessments. Inference from adult trapping datasets involves comparing populations across space and time, but comparisons ...
Erin E. Gorsich, Brianna R. Beechler, Peter M. van Bodegom, Danny Govender, Milehna M. Guarido, Marietjie Venter, Maarten Schrama   +6 more
doaj   +1 more source

Influenza virus respiratory infection and transmission following ocular inoculation in ferrets. [PDF]

PLoS Pathogens, 2012
While influenza viruses are a common respiratory pathogen, sporadic reports of conjunctivitis following human infection demonstrates the ability of this virus to cause disease outside of the respiratory tract.
Jessica A Belser, Kortney M Gustin, Taronna R Maines, Mary J Pantin-Jackwood, Jacqueline M Katz, Terrence M Tumpey   +5 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source