Results 81 to 90 of about 569,278 (268)

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Landscape of respiratory syncytial virus

Chinese Medical Journal
Abstract Respiratory syncytial virus (RSV) is an enveloped, negative-sense, single-stranded RNA virus of the Orthopneumovirus genus of the Pneumoviridae family in the order Mononegavirales. RSV can cause acute upper and lower respiratory tract infections, sometimes with extrapulmonary complications.
Yuping Duan, Zimeng Liu, Na Zang, Bingbing Cong, Yuqing Shi, Lili Xu, Mingyue Jiang, Peixin Wang, Jing Zou, Han Zhang, Ziheng Feng, Luzhao Feng, Lili Ren, Enmei Liu, You Li, Yan Zhang, Zhengde Xie, Jing Ni   +17 more
openaire   +3 more sources

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

SARS-CoV-2 strains bearing Omicron BA.1 spike replicate in C57BL/6 mice

Frontiers in Immunology
IntroductionSARS-CoV-2, the cause of the COVID pandemic, is an RNA virus with a high propensity to mutate. Successive virus variants, including variants of concern (VOC), have emerged with increased transmission or immune escape.
Patricia P. Ogger, Minerva Garcia Martín, Soyeon Jang, Jie Zhou, Jonathan Brown, Ksenia Sukhova, Wilhelm Furnon, Arvind H. Patel, Vanessa Cowton, Massimo Palmarini, Wendy S. Barclay, Cecilia Johansson   +11 more
doaj   +1 more source

Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

The Lancet Global Health, 2019
Summary: Background: Influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus are the most common viruses associated with acute lower respiratory infections in young children (
You Li, MSc, Rachel M Reeves, PhD, Xin Wang, MSc, Quique Bassat, ProfMD, W Abdullah Brooks, MD, Cheryl Cohen, PhD, David P Moore, PhD, Marta Nunes, PhD, Barbara Rath, ProfPhD, Harry Campbell, ProfMD, Harish Nair, ProfPhD, Sozinho Acacio, Wladimir J Alonso, Martin Antonio, Guadalupe Ayora Talavera, Darmaa Badarch, Vicky L Baillie, Gisela Barrera-Badillo, Godfrey Bigogo, Shobha Broor, Dana Bruden, Philippe Buchy, Peter Byass, James Chipeta, Wilfrido Clara, Duc-Anh Dang, Carla Cecília de Freitas Lázaro Emediato, Menno de Jong, José Alberto Díaz-Quiñonez, Lien Anh Ha Do, Rodrigo A Fasce, Luzhao Feng, Mark J Ferson, Angela Gentile, Bradford D Gessner, Doli Goswami, Sophie Goyet, Carlos G Grijalva, Natasha Halasa, Orienka Hellferscee, Danielle Hessong, Nusrat Homaira, Jorge Jara, Kathleen Kahn, Najwa Khuri-Bulos, Karen L Kotloff, Claudio F Lanata, Olga Lopez, Maria Renee Lopez Bolaños, Marilla G Lucero, Florencia Lucion, Socorro P Lupisan, Shabir A Madhi, Omphile Mekgoe, Cinta Moraleda, Jocelyn Moyes, Kim Mulholland, Patrick K Munywoki, Fathima Naby, Thanh Hung Nguyen, Mark P Nicol, D James Nokes, Daniel E Noyola, Daisuke Onozuka, Nandhini Palani, Yong Poovorawan, Mustafizur Rahman, Kaat Ramaekers, Candice Romero, Elizabeth P Schlaudecker, Brunhilde Schweiger, Phil Seidenberg, Eric A F Simoes, Rosalyn Singleton, Sujatha Sistla, Katharine Sturm-Ramirez, Nungruthai Suntronwong, Agustinus Sutanto, Milagritos D Tapia, Somsak Thamthitiwat, Ilada Thongpan, Gayani Tillekeratne, Yeny O Tinoco, Florette K Treurnicht, Claudia Turner, Paul Turner, Rogier van Doorn, Marc Van Ranst, Benoit Visseaux, Sunthareeya Waicharoen, Jianwei Wang, Lay-Myint Yoshida, Heather J Zar   +92 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source