Results 211 to 220 of about 2,828,940 (313)

Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models

Animal Models and Experimental Medicine, EarlyView.
We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv, Ming Liu, Feifei Qi, Mingya Liu, Fengdi Li, Ran Deng, Xujian Liang, Yanfeng Xu, Zhiqi Song, Yiwei Yan, Shuyue Li, Guocui Mou, Linlin Bao   +12 more
wiley   +1 more source

Direct and Ultrasensitive Bioluminescent Detection of Intact Respiratory Viruses. [PDF]

ACS Sens
Gräwe A, van der Veer H, Jongkees SAK, Flipse J, Rossey I, de Vries RP, Saelens X, Merkx M.   +7 more
europepmc   +1 more source

Advances in CRISPR‐Cas9 in lineage tracing of model animals

Animal Models and Experimental Medicine, EarlyView.
Cell lineage tracing is a key technology for describing the developmental history of individual progenitor cells and assembling them to form a lineage development tree. However, traditional methods have limitations of poor stability and insufficient resolution.
Jingchao Cao, Zihang Guo, Xueling Xu, Pan Li, Yi Fang, Shoulong Deng   +5 more
wiley   +1 more source

From Epidemics to Pandemics: Over a Decade of Strengthening SARInet Laboratory Surveillance and Response for Respiratory Viruses in the Americas. [PDF]

J Infect Dis
Leite JA, Born PS, Rodríguez Á, Couto P, Cerpa M, Gabastou JM, Gresh L, Franco L, Martínez MG, Sugasti M, Jara JH, Rodondo-Bravo L, Perkins IW, Villalobos Rodríguez AP, Ramirez R, Terrazas X, Barbosa J, Rondy M, Vicari AS, Aldighieri S, Webby R, Zhang W, Pereyaslov D, Samaan M, Méndez-Rico J, SARInet plus laboratory network .   +25 more
europepmc   +1 more source

Bifidobacterium animalis subsp. lactis modulates early‐life immune response and gut metabolism

Animal Models and Experimental Medicine, EarlyView.
Background: The maturation of the immune system is critical during early life, as it involves the differentiation, maturation, and establishment of immune tolerance of immune cells. This process is influenced not only by genetic factors but also by environmental factors, particularly the symbiotic microbiota. Bifidobacterium animalis subsp.
Haoming Du, Yiran Cai, Lulu Shen, Yuxing Zheng, Lingling Zhao, Ruibiao Hu, Shan Jiang, Jiajia Yuan, Chengming Hu, Qi Deng, Jiaoyan Huang, Jingbo Hu, Yuexiang Wang, Jing Tan, Jiahui Chen, Feitong Liu, Yuanyuan Duan, Haitao Niu   +17 more
wiley   +1 more source

New questions and avenues for research regarding interpretation of the significance of respiratory viruses adrift in the air. [PDF]

EBioMedicine
Lednicky JA.
europepmc   +1 more source

Effectiveness of Autologous Hematopoietic Stem Cell Transplantation versus Alemtuzumab and Ocrelizumab in Relapsing Multiple Sclerosis: A Single Center Cohort Study

Annals of Neurology, EarlyView.
Objective To compare clinical and radiological outcomes among relapsing multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT), alemtuzumab (ATZ), and ocrelizumab (OCR). Methods From a London (UK) hospital‐based observational cohort, modeled data were obtained from 621 relapsing–remitting multiple sclerosis ...
Paolo Antonio Muraro, Antonio Zito, Alessio Signori, Maria Pia Sormani, Eleonora Rigoni, Federica Pollidoro, Roberto Bergamaschi, Alice Mariottini, Omar Malik, Ashwini Nandoskar, Victoria Singh‐Curry, Varun Mehra, Majid Kazmi, Ian Gabriel, Eli Silber, Richard Nicholas, Antonio Scalfari   +16 more
wiley   +1 more source

Assessment of the prevalence of respiratory pathogens and the level of immunity to respiratory viruses in soldiers and civilian military employees in Poland. [PDF]

Respir Res
Nakonieczna A, Kwiatek M, Abramowicz K, Zawadzka M, Bany I, Głowacka P, Skuza K, Lepionka T, Szymański P.   +8 more
europepmc   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

An integrated airborne transmission risk assessment model for respiratory viruses: short- and long-range contributions. [PDF]

J R Soc Interface
Henriques A, Jia W, Aleixo L, Mounet N, Fontana L, Simniceanu A, Devine J, Elson P, Azzopardi G, Rognlien M, Andreini M, Tarocco N, Keiser O, Li Y, Tang JW.   +14 more
europepmc   +1 more source