Results 101 to 110 of about 8,120 (200)

Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta‐Cell Function

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
In the non‐diabetic beta‐cell (top left) activation of glucokinase (bottom left) leads to inhibition of mitochondrial metabolism and thereby impairs insulin secretion. The effect is similar to that of chronic hyperglycaemia as seen in the diabetic beta‐cell (top right).
Matthew Lloyd   +9 more
wiley   +1 more source

Metabolic Rate of Goldfish (Carassius auratus) in the Face of Common Aquaculture Challenges

open access: yesBiology
This study examined the metabolic rate (MO2, oxygen consumption) of goldfish (Carassius auratus) under normal management conditions in aquaculture.
Lisbeth Herrera-Castillo   +6 more
doaj   +1 more source

Mitochondrial function predicts dominance status in brown trout

open access: yesFunctional Ecology, Volume 40, Issue 4, Page 816-829, April 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract In social hierarchies, winning contests confers better access to food, shelter and reproductive opportunities. Clear dominance relationships are often apparent even when opponents are matched for experience, age, size and other obvious characteristics.
Darryl McLennan   +5 more
wiley   +1 more source

The energetic consequences of oxygen fluxes in a coral reef fish

open access: yesFunctional Ecology, Volume 40, Issue 4, Page 844-856, April 2026.
Abstract Ocean warming elevates metabolic rates in marine ectotherms but often constrains energetic resources, causing an imbalance between supply and demand. Transient hypoxia is near‐ubiquitous across the world's coral reefs and may exacerbate this imbalance, yet its effects on the energetics of reef fishes remain poorly understood. In this study, we
Daniel M. Ripley   +3 more
wiley   +1 more source

Local climate and genetic influence on intraspecific variation in torpor physiology of a cave‐roosting bat

open access: yesFunctional Ecology, Volume 40, Issue 4, Page 857-867, April 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Many small endotherms employ torpor as a survival strategy to reduce energy expenditure during periods with low food availability and cold temperatures. The expression and physiology of torpor can vary substantially within species because of phenotypic plasticity and ...
Nicholas C. Wu   +2 more
wiley   +1 more source

Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators

open access: yesAging Cell, Volume 25, Issue 4, April 2026.
Terbinafine and miglustat are mitohormetic compounds that extend lifespan and healthspan. In C. elegans, these FDA‐approved drugs engage both ATFS‐1 and DAF‐16, highlighting a stress‐dependent coordination between mitochondrial and IIS pathways distinct from canonical IIS activation, relevant for healthy aging.
Amélia Lalou   +15 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

HomoTherm: An Open‐Source Approach to Modelling Heat Exchange in Humans and Other Hominins in Diverse Environments

open access: yesGlobal Change Biology, Volume 32, Issue 4, April 2026.
We present ‘HomoTherm’, a human heat budget model for simulating humans and related species with diverse traits in diverse environments. It is part of the NicheMapR package for biophysical modelling and is a multi‐part extension of the ‘endoR’ function.
Michael R. Kearney   +2 more
wiley   +1 more source

Effect of live‐high, train‐low strategy induced by chronic low‐dose carbon monoxide exposure on haematological parameters and performance in trained individuals

open access: yesExperimental Physiology, Volume 111, Issue 4, Page 1891-1903, 1 April 2026.
Abstract Altitude training enhances haematological adaptations and endurance at sea level, typically requiring exposure to ∼2500 m altitude for 3–4 weeks. Emerging evidence suggests that low‐dose carbon monoxide (CO) inhalation might mimic hypoxia and might be used by elite athletes.
Simone Villanova   +3 more
wiley   +1 more source

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

open access: yesExperimental Physiology, Volume 111, Issue 4, Page 1643-1651, 1 April 2026.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham   +4 more
wiley   +1 more source

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