Results 121 to 130 of about 2,704,258 (334)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Neural Correlates of Response Inhibition and Conflict Control on Facial Expressions
Frontiers in Human Neuroscience, 2018 Response inhibition and conflict control on affective information can be regarded as two important emotion regulation and cognitive control processes.
Tongran Liu +5 more
doaj +1 more source
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria [PDF]
, 2009 Lijuan Xu +4 more
openalex +1 more source
Effects of focal frontal lesions on response inhibition [PDF]
, 2007 This study examined the performance of 38 normal subjects and 43 patients with focal lesions of the frontal lobes on a simple go-nogo task where the probability of the nogo stimulus was either 75% or 25%.
Alexander, MP +5 more
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Frontiers in Psychiatry, 2013 Disinhibition is present in various maladaptive behaviours, including substance use disorders. Most previous research has assumed that disinhibition is a psychological construct that is relatively stable within individuals.
Andrew eJones +4 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Frontiers in Human Neuroscience, 2015 Being able to stop (or inhibit) an action rapidly as in a stop-signal task is an essential human ability. Previous studies showed that when a pre-stimulus cue warned of the possible need to stop a response in an upcoming trial, participants’ response ...
Benjamin eXu +7 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
HSP90 inhibition without heat shock response [PDF]
Blood, 2018 In this issue of Blood, Bhatia and colleagues describe a heat shock protein 90 (HSP90) C-terminal dimerization inhibitor with mechanistic differences that distinguish it from other clinically unsuccessful N-terminal ATPase binding compounds.1 Can graveyard raiding of an old therapeutic target with a new strategy bring long awaited success?
openaire +2 more sources