Results 101 to 110 of about 13,505,920 (341)

Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]

, 2012
The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A, Christopher J. Weston, David H. Adams, Munafo´ DB, Ricky H. Bhogal, Schroedl C, Simon C. Afford, Stuart M. Curbishley   +7 more
core   +1 more source

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Patients with microsatellite stable (MSS) pancreatic (PDA) or colorectal cancer (CRC) do not respond to immunotherapy with inhibitors of T cell checkpoints. A possible explanation is suggested by finding that cancer cells in these tumors are
D. Biasci, M. Smoragiewicz, Claire M. Connell, Zhikai Wang, Ya Gao, James E. D. Thaventhiran, B. Basu, Lukasz Magiera, Isaac T. Johnson, L. Bax, A. Gopinathan, Christopher Isherwood, F. Gallagher, M. Pawula, I. Hudecova, D. Gale, N. Rosenfeld, P. Barmpounakis, E. Popa, R. Brais, E. Godfrey, Fraz A Mir, F. Richards, D. Fearon, T. Janowitz, D. Jodrell   +25 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Optimal designs for enzyme inhibition kinetic models [PDF]

, 2017
In this paper we present a new method for determining optimal designs for enzyme inhibition kinetic models, which are used to model the influence of the concentration of a substrate and an inhibition on the velocity of a reaction.
Dette, Holger, Kettelhake, Katrin, Möller, Tilman, Schorning, Kirsten   +3 more
core   +2 more sources

Improving Response Inhibition in Parkinson’s Disease with Atomoxetine

Biological Psychiatry, 2015
Background Dopaminergic drugs remain the mainstay of Parkinson’s disease therapy but often fail to improve cognitive problems such as impulsivity.
Z. Ye, E. Altena, C. Nombela, C. Housden, Helen Maxwell, T. Rittman, Chelan Huddleston, Charlotte L. Rae, R. Regenthal, B. Sahakian, R. Barker, T. Robbins, J. Rowe   +12 more
semanticscholar   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Executive control and felt concentrative engagement following intensive meditation training

Frontiers in Human Neuroscience, 2013
Various forms of mental training have been shown to improve performance on cognitively demanding tasks. Individuals trained in meditative practices, for example, show generalized improvements on a variety of tasks assessing attentional performance.
Anthony Paul Zanesco, Anthony Paul Zanesco, Brandon eKing, Brandon eKing, Katherine eMacLean, Clifford D Saron, Clifford D Saron, Clifford D Saron   +7 more
doaj   +1 more source

Sex Differences in Aripiprazole Sensitization from Adolescence to Adulthood [PDF]

, 2018
The present study investigated the potential sex differences in repeated aripiprazole (ARI) treatment-induced behavioral sensitization from adolescence to adulthood, and to determine whether ARI sensitization can be transferred to olanzapine (OLZ) and/or
Chow, Shinnyi, Davis, Collin, Freeman, Elizabeth, Li, Ming, Lin, Joanne   +4 more
core   +1 more source

Striatal D1- and D2-type Dopamine Receptors Are Linked to Motor Response Inhibition in Human Subjects

Journal of Neuroscience, 2015
Motor response inhibition is mediated by neural circuits involving dopaminergic transmission; however, the relative contributions of dopaminergic signaling via D1- and D2-type receptors are unclear. Although evidence supports dissociable contributions of
C. Robertson, K. Ishibashi, M. Mandelkern, Amira K. Brown, D. Ghahremani, F. Sabb, R. Bilder, T. Cannon, J. Borg, E. London   +9 more
semanticscholar   +1 more source