Results 91 to 100 of about 7,596,663 (297)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

How Does Not Responding to Appetitive Stimuli Cause Devaluation: Evaluative Conditioning or Response Inhibition?

, 2016
In a series of 6 experiments, we examined how not responding to appetitive stimuli causes devaluation. To examine this question, a go/no-go task was employed in which appetitive stimuli were consistently associated with cues to respond (go stimuli), or ...
Veling, dr. H.P. (RU Radboud Universiteit) DAI=info:eu-repo/dai/nl/298978520, Dijksterhuis, prof. dr. A.J. (RU Radboud Universiteit) DAI=info:eu-repo/dai/nl/153149493, Chen, MSc Z. (RU Radboud Universiteit) DAI=info:eu-repo/dai/nl/401559610, Holland, prof. dr. R.W. (RU Radboud Universiteit) DAI=info:eu-repo/dai/nl/202163954   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model [PDF]

, 2002
Background: Incentive-motivation models of addiction suggest impairment of functional activity in mesocorticolimbic reward pathways during abstinence.
Davis, Robert E., Dawkins, Lynne, Powell, Jane H.   +2 more
core  

The Effect of Item Similarity and Response Competition Manipulations on Collaborative Inhibition in Group Recall

, 2017
Collaborative inhibition refers to when people working together remember less than their predicted potential. The most common explanation for this effect is the retrieval-disruption hypothesis during collaborative recall.
Shi, Jiannong, Yao Fu, Xingli Zhang, Jiannong Shi, Zhang, Huan, Fu, Yao, Huan Zhang, Zhang, Xingli   +7 more
core   +1 more source

Executive "brake failure" following deactivation of human frontal lobe [PDF]

, 2005
In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance.
Stokes, Mark, Mark A. Bellgrove, Mattingley, J, Bellgrove, M. A., Stokes, M, Jason B. Mattingley, Garavan, Hugh, Chambers, C, Ian H. Robertson, Mattingley, JB, Garavan, H, Adam P. Morris, Morris, A.P., Henderson, T. R., Bellgrove, M, Chambers, CD, Bellgrove, M.A., Robertson, I.H., Hugh Garavan, Robertson, I. H., Stokes, M. G., Mattingley, J. B., Henderson, Tracy R., Mattingley, Jason B., Henderson, T.R., Garavan, H., Henderson, TR, Chambers, C.D., Tracy R. Henderson, Robertson, Ian H., Mattingley, J.B., Christopher D. Chambers, Stokes, MG, Henderson, T, Morris, AP, Stokes, Mark G., Stokes, M.G., Bellgrove, MA, Chambers, Christopher D., Robertson, I, Morris, A. P., Morris, Adam P., Robertson, IH, Mark G. Stokes, Bellgrove, Mark A., Chambers, C. D.   +45 more
core   +1 more source

Electrophysiological correlates for response inhibition in intellectually gifted children: A Go/NoGo study

, 2009
Superior response inhibition is an essential component of the advanced cognitive abilities of gifted children. This study investigated response inhibition in intellectually gifted children by recording event-related brain potentials (ERPs) during a Go ...
Duan, Xiaoju, Shi, Jiannong, Jiannong Shi, Cui, Hairong, Wu, Jianhui, Mou, Yi, Wang, Guiqing   +6 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source