Results 91 to 100 of about 1,787,447 (311)

The Impact of Dexamphetamine Treatment for Obesity on Executive Function: A Double-Blind Randomised Controlled Pilot Study

Brain Sciences
Background: Amphetamines increase dopamine levels in mid-brain regions which, in turn, impact top-down executive function. Repeated exposure is linked to substance use disorders.
Antoinette Poulton, Natalie Gauci, Hazer Khalifa, Emily J. Hibbert, Alison S. Poulton   +4 more
doaj   +1 more source

Fluctuating disinhibition: Implications for the understanding and treatment of alcohol and other substance use disorders

Frontiers in Psychiatry, 2013
Disinhibition is present in various maladaptive behaviours, including substance use disorders. Most previous research has assumed that disinhibition is a psychological construct that is relatively stable within individuals.
Andrew eJones, Paul eChristiansen, Chantal eNederkoorn, Katrijn eHouben, Matt eField   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model [PDF]

, 2002
Background: Incentive-motivation models of addiction suggest impairment of functional activity in mesocorticolimbic reward pathways during abstinence.
Davis, Robert E., Dawkins, Lynne, Powell, Jane H.   +2 more
core  

Effect of foreknowledge on neural activity of primary go responses relates to response stopping and switching

Frontiers in Human Neuroscience, 2015
Being able to stop (or inhibit) an action rapidly as in a stop-signal task is an essential human ability. Previous studies showed that when a pre-stimulus cue warned of the possible need to stop a response in an upcoming trial, participants’ response ...
Benjamin eXu, Sarah eLevy, John eButman, Dzung ePham, Dzung ePham, Leonardo G Cohen, Marco eSandrini, Marco eSandrini   +7 more
doaj   +1 more source

Comparison of executive functions in addicted young people who referred to addiction treatment camps with students

Cogent Psychology, 2020
Background and aim: Cerebral areas related to executive functions, during adolescence and early youth encounter with structural and functional changes and fluctuations that expose adolescents to many problems including drug abuse.
Abdollah Salmani, Mghsoud Nader pilehroud, Maryam jammali   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differences

, 2005
We investigated the role of GABAergic inhibition on the responses of inferior colliculus (IC) neurons sensitive to interaural time differences (ITDs) in anesthetized guinea pigs.
Ingham, NJ, Mcalpine, D
core