Results 91 to 100 of about 6,246,204 (255)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Frontiers in Human Neuroscience, 2015 Being able to stop (or inhibit) an action rapidly as in a stop-signal task is an essential human ability. Previous studies showed that when a pre-stimulus cue warned of the possible need to stop a response in an upcoming trial, participants’ response ...
Benjamin eXu +7 more
doaj +1 more source
Cogent Psychology, 2020 Background and aim: Cerebral areas related to executive functions, during adolescence and early youth encounter with structural and functional changes and fluctuations that expose adolescents to many problems including drug abuse.
Abdollah Salmani +2 more
doaj +1 more source
, 2017 Collaborative inhibition refers to when people working together remember less than their predicted potential. The most common explanation for this effect is the retrieval-disruption hypothesis during collaborative recall.
Shi, Jiannong +7 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2009 Superior response inhibition is an essential component of the advanced cognitive abilities of gifted children. This study investigated response inhibition in intellectually gifted children by recording event-related brain potentials (ERPs) during a Go ...
Duan, Xiaoju +6 more
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An Examination Of Response Inhibition In Operant Conditioning [PDF]
, 2022 Operant or instrumental behaviors become inhibited in a number of experimental procedures. In extinction, a reinforced response is allowed to occur without reinforcement, and the response declines over time.
Steinfeld, Michael
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