Results 231 to 240 of about 10,606,337 (342)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Impaired emotional response inhibition among adolescents with bipolar depression: evidence from event-related potentials and behavioral performance. [PDF]

BMC Psychiatry
Chen F, Chen C, Wu M, Luo B, Cai H, Yu F, Wang L.   +6 more
europepmc   +1 more source

Transcranial focused ultrasound to human rIFG improves response inhibition through modulation of the P300 onset latency. [PDF]

Elife, 2023
Fine JM, Mysore AS, Fini ME, Tyler WJ, Santello M.   +4 more
europepmc   +1 more source

Clinical anxiety promotes excessive response inhibition

Psychological Medicine, 2016
C. Grillon, O. Robinson, K. O’Connell, A. Davis, G. Alvarez, D. Pine, M. Ernst   +6 more
semanticscholar   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Deficits in general and smoking-specific response inhibition in the Go/No-Go task in individuals who smoke: A cross-sectional analysis. [PDF]

Addiction
Motka F, Kühn S, Wittekind CE.
europepmc   +1 more source

Overlapping and unique brain responses to cognitive and response inhibition. [PDF]

Brain Cogn, 2023
Feola B, Sand L, Atkins S, Bunting M, Dougherty M, Bolger DJ.   +5 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Tired and out of control? Effects of total and partial sleep deprivation on response inhibition under threat and no-threat conditions. [PDF]

Sleep
Nieuwenhuys A, Wadsley CG, Sullivan R, Cirillo J, Byblow WD.   +4 more
europepmc   +1 more source

Stop it! Relationship between sport expertise and response inhibition in elite athletes. [PDF]

Front Psychol, 2023
Fleddermann MT, Reichert L, Wieland B, Zentgraf K.   +3 more
europepmc   +1 more source