Results 91 to 100 of about 2,843,245 (304)

Derivation of equivalent linear properties of Bouc-Wen hysteretic systems for seismic response spectrum analysis via statistical linearization [PDF]

, 2013
A newly proposed statistical linearization based formulation is used to derive effective linear properties (ELPs), namely damping ratio and natural frequency, for stochastically excited hysteretic oscillatorsinvolving the Bouc-Wen force-deformation ...
Giaralis, A., Spanos, P. D.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Incorporation of rubber-steel bearing isolation in multi-storey muilding

Journal of Civil Engineering and Management, 2014
Base isolation incorporation has moved towards a popular technology in the seismic vulnerable regions. The system mitigates lateral action of tremor hazard providing flexibility of structures.
A. B. M. Saiful Islam, Mohd Zamin Jumaat, Raja Hussain, Md Ashraful Alam   +3 more
doaj   +1 more source

Design Spectrum Analysis in NASTRAN [PDF]

, 1984
The utility of Design Spectrum Analysis is to give a mode by mode characterization of the behavior of a design under a given loading. The theory of design spectrum is discussed after operations are explained.
Butler, T. G.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Chaotic response of global climate to long-term solar forcing variability

, 2009
It is shown that global climate exhibits chaotic response to solar forcing variability in a vast range of timescales: from annual to multi-millennium. Unlike linear systems, where periodic forcing leads to periodic response, nonlinear chaotic response to
Bershadskii, A.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Response-Spectrum Uncoupled Analyses for Seismic Assessment of Offshore Wind Turbines

Journal of Marine Science and Engineering, 2018
According to International Standards and Guidelines, the seismic assessment of offshore wind turbines in seismically-active areas may be performed by combining two uncoupled analyses under wind-wave and earthquake loads, respectively.
Giuseppe Failla, Fabio Santangelo, Gabriele Foti, Fabio Scali, Felice Arena   +4 more
doaj   +1 more source

Memoryless nonlinear response: A simple mechanism for the 1/f noise

, 2013
Discovering the mechanism underlying the ubiquity of $"1/f^{\alpha}"$ noise has been a long--standing problem. The wide range of systems in which the fluctuations show the implied long--time correlations suggests the existence of some simple and general ...
Dhar, Deepak, Ramaswamy, Ramakrishna, Yadav, Avinash Chand   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source