Results 101 to 110 of about 2,843,245 (304)

Note on the Extraction of |V_{ub}| using Radiative B Decays

, 2001
The element |V_{ub}| of the quark mixing matrix can be extracted with small theoretical uncertainties by combining weighted integrals over the endpoint regions of the lepton spectrum in B -> X_u l nu decays and the photon spectrum in B -> X_s gamma ...
Ali, Bigi, Buchalla, Chetyrkin, Falk, Gambino, Grant, Greub, Greub, Jezabek, Kagan, Khodjamirian, Korchemsky, Leibovich, Leibovich, Ligeti, Matthias Neubert, Neubert, Neubert, Voloshin   +19 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Modal seismic analysis of a nuclear power plant control panel and comparison with SAP 4 [PDF]

, 1976
The application of NASTRAN to seismic analysis by considering the example of a nuclear power plant control panel was considered. A modal analysis of a three-dimensional model of the panel, consisting of beam and quadri-lateral membrane elements, is ...
Pamidi, M. R., Pamidi, P. R.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Simulation study on impact characteristics of RF microsystem based on bulk silicon MEMS process

Dianzi Jishu Yingyong
The high overload impact test is costly and time consuming, and the failure detection means are few, so it is difficult to locate the weak points of the structure. In this paper the impact response spectrum and transient dynamics method are used to study
Feng Zhengsen, Wang Lu, Zeng Yanping, Yang Bing, Qi Dong, Wang Zhihui, Zhang Rui   +6 more
doaj   +1 more source

Response approach to the squeezed-limit bispectrum: application to the correlation of quasar and Lyman-$\alpha$ forest power spectrum

, 2017
The squeezed-limit bispectrum, which is generated by nonlinear gravitational evolution as well as inflationary physics, measures the correlation of three wavenumbers, in the configuration where one wavenumber is much smaller than the other two. Since the
Chiang, Chi-Ting, Cieplak, Agnieszka M., Schmidt, Fabian, Slosar, Anže   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Brownian Motion Model of Parametric Correlations in Ballistic Cavities

, 1995
A Brownian motion model is proposed to study parametric correlations in the transmission eigenvalues of open ballistic cavities. We find interesting universal properties when the eigenvalues are rescaled at the hard edge of the spectrum.
A. D. Stone, A. M. S. Macêdo, A. M. S. Macědo, A. M. S. Macědo, A. M. S. Macědo, A. M. S. Macědo, A. Szafer, A. V. Andreev, B. D. Simons, B. D. Simons, B. D. Simons, B. D. Simons, B. D. Simons, B. D. Simons, B. D. Simons, B. L. Altschuler, B. L. Altshuler, B. V. Bronk, C. A. Tracy, C. A. Tracy, C. H. Lewenkopf, C. W. J. Beenakker, C. W. J. Beenakker, C. W. J. Beenakker, C. W. J. Beenakker, C. W. J. Beenakker, C. W. J. Beenakker, D. Braun, D. Saher, E. Brézin, E. Brézin, E. Doron, E. P. Wigner, E. R. Mucciolo, F. Haake, F. J. Dyson, G. Bergmann, G. Montambaux, G. Szegö, H. Risken, H. U. Baranger, H. U. Baranger, J. Goldberg, J. J. M. Verbaarschot, J. Rau, J. T. Chalker, J. Zakrzewski, J. Zakrzewski, K. B. Efetov, K. Frahm, K. Slevin, K. Slevin, L. P. Gorkov, M. Faas, M. Hamermesh, M. L. Mehta, M. Wilkinson, M. Wilkinson, M. Wilkinson, O. N. Dorokhov, P. A. Lee, P. A. Lee, P. A. Mello, P. A. Mello, P. Gaspard, P. Gaspard, P. J. Forrester, R. A. Jalabert, R. Blümel, R. Blümel, R. Blümel, R. Kubo, T. Nagao, V. E. Kravtsov   +73 more
core   +1 more source