Results 101 to 110 of about 2,820,746 (300)
Simulation study on impact characteristics of RF microsystem based on bulk silicon MEMS process
Dianzi Jishu YingyongThe high overload impact test is costly and time consuming, and the failure detection means are few, so it is difficult to locate the weak points of the structure. In this paper the impact response spectrum and transient dynamics method are used to study
Feng Zhengsen +6 more
doaj +1 more source
Quantum-Mechanical Non-Perturbative Response of Driven Chaotic Mesoscopic Systems
, 2000 Consider a time-dependent Hamiltonian $H(Q,P;x(t))$ with periodic driving $x(t)=A\sin(\Omega t)$. It is assumed that the classical dynamics is chaotic, and that its power-spectrum extends over some frequency range $|\omega|\omega_{cl}$, and the shape of ...
A. Bulgac +25 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Criteria for vibration testing [PDF]
, 1971 Systematic application of response spectral analysis and other analyses determine damping sensitivity of flight environment and candidate laboratory tests.
Cronin, D. L.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Study of a Large NaI(Tl) Crystal
, 2010 Using a narrow band positron beam, the response of a large high-resolution NaI(Tl) crystal to an incident positron beam was measured. It was found that nuclear interactions cause the appearance of additional peaks in the low energy tail of the deposited ...
A. Aguilar-Arevalo +24 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
, 2018 A current challenge for ab initio calculations is systems that contain large continuum contributions such as 8Be. We report on new measurements of radiative decay widths in this nucleus that test recent Green's function Monte Carlo calculations ...
Fynbo, Hans Otto Uldall +4 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source