Results 101 to 110 of about 12,593,396 (297)

Response Surface Methodology's Steepest Ascent and Step Size Revisited [PDF]

Response Surface Methodology (RSM) searches for the input combination maximizing the output of a real system or its simulation.RSM is a heuristic that locally fits first-order polynomials, and estimates the corresponding steepest ascent (SA) paths ...
Angun, M.E., Kleijnen, J.P.C., Hertog, D. den   +2 more
core  

Engineering optimization of silver nanoparticle synthesis using Clitoria ternatea leaf extract: response surface methodology approach and biocompatibility assessment

Chemical Physics Impact
The biological fabrication of nanoparticles utilizing botanical extracts has gained significant attention due to its environmentally friendly and sustainable approach. In this investigation, silver nanoparticles (AgNPs) were successfully produced through
Madheslu Manikandan, Divya Prabhakaran, Narendhran Sadasivam, Muthupandi Sankar, Saravanan Muthupandian, Osama M. Al-Amer, Faisal Altemani, Zeyad Alharbi   +7 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

CO2 mineralization using basic oxygen furnace slag: process optimization by response surface methodology

, 2016
The basic oxygen furnace steelmaking slag (SL) is employed for CO2 mineralization. Response surface methodology and the central composite design were employed in determining the optimal condition.
Zhang, Lian, Sun, Yong, Li, Kevin, Yang, Gang, Zhang, Lai-Chang   +4 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Optimizing gefitinib nanoliposomes by Box-Behnken design and coating with chitosan: A sequential approach for enhanced drug delivery

ADMET and DMPK
This study aimed to improve the stability and prolonged gefitinib release from the nanoliposomes. Nanoliposomes were prepared by reverse-phase evaporation and optimized using Box-Behnken design to investigate the influence of sonication time (X1), tween
Seema Rohilla, Rajendra Awasthi, Ankur Rohilla, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Harish Dureja   +6 more
doaj   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Optimizing flexural performance of 3D fibre-reinforced composites with hybrid nano-fillers using response surface methodology (RSM) [PDF]

This study presents the flexural performance and damage mechanism of three-dimensional orthogonal woven E-glass/epoxy composites (3DOWC) modified with an innovative toughened epoxy resin using different weight percentages of Nanostrength® (NS: up to 7.5 ...
Shah, S. Z. H., Sharif, T., Hussain, M. Z., Megat-Yusoff, P. S. M., Hussnanim, S. M.   +4 more
core   +1 more source

Isolation, identification and optimization of biomass production of native Spirulina species from South of the Caspian Sea

MethodsX
The aim of the present study was to identify the native Spirulina species from Caspian Sea and optimize the growth conditions of this microalgae in order to reduce costs and increase the benefits of its production.
Matin Shakoori, Reza Safari, Asieh Makhlough, Tahereh Bagheri   +3 more
doaj   +1 more source

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source