Results 81 to 90 of about 1,569,701 (307)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Future directions in response surface methodology for simulation [PDF]

Proceedings of the 19th conference on Winter simulation - WSC '87, 1987
As a tool for gradient estimation and sensitivity analysis in discrete simulation, response surface methodology possesses noteworthy advantages in comparison to some of the more recently developed techniques. This paper surveys future directions for research, development, and application of response surface methodology in discrete simulation.
openaire   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Minimizing surface roughness and back wall dross for fiber laser micro-cutting on AISI 316 L tubes using response surface methodology

Materials Research Express
A response surface methodology (RSM) was performed to study the influence of spot overlapping and pulse energy on back wall dross and surface roughness for fiber laser cutting of AISI 316 L stainless steel minitubes.
Erika García-López, Hector Siller, Elisa Vazquez-Lepe, José Guillermo Ramirez-Galindo, Ciro A Rodriguez   +4 more
doaj   +1 more source

Optimized microwave-assisted azadirachtin extraction using response surface methodology

Heliyon
The neem tree (Azadirachta indica A. Juss) is grown mainly for shade, fuel, and numerous non-timber forest products using its leaves, fruit, and bark.
Robinson Martínez-Castro, Jiress Flórez-Santiago, Roger Valle-Molinares, Julián Cabrera-Barraza, Fabián Espitia-Almeida   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Optimization of Pectinase Production from Bacillus velezensis Isolated from Agro-waste using Response Surface Methodology

Journal of Pure and Applied Microbiology
Pectinases are important enzymes with significant applications in the industrial processing of juice clarification, oil and tea extraction, and paper manufacturing.
Lakshmi Suresh Kottilingal, Sivagurunathan Paramasivam, Sowndarya Sivaprakasam, Chakrappully Radhakrishnan Meera, Uma Chinnaiyan   +4 more
doaj   +1 more source

Optimization of Aqueous Extraction Conditions for Recovery of Phenolic Content and Antioxidant Properties from Macadamia (Macadamia tetraphylla) Skin Waste

Antioxidants, 2015
The macadamia is native to Australia and is now grown commercially around the world. Macadamia skin, known as waste, has been generated abundantly, but this ample source has had limited uses as a byproduct.
Adriana Dailey, Quan V. Vuong
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source