Results 61 to 70 of about 1,569,701 (307)

The possibilities of wheat roller milling optimization using the response surface methodology [PDF]

Journal on Processing and Energy in Agriculture, 2017
Roller mills are one of the most frequently used grinding machines especially for cereal milling. Magnitude and type of the forces acting on particle depend on the set of roll parameters.
Fišteš Aleksandar, Rakić Dušan, Vukmirović Đuro, Bojanić Nemanja   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Generalized Response Surface Methodology: A New Metaheuristic [PDF]

SSRN Electronic Journal, 2006
Generalized Response Surface Methodology (GRSM) is a novel general-purpose metaheuristic based on Box and Wilson.s Response Surface Methodology (RSM).Both GRSM and RSM estimate local gradients to search for the optimal solution.These gradients use local first-order polynomials.GRSM, however, uses these gradients to estimate a better search direction ...
openaire   +4 more sources

Response surface methodology and its application in simulation [PDF]

Proceedings of the 25th conference on Winter simulation - WSC '93, 1993
The contents of this paper reflect a portion of the conference tutorial on the application of response surface methodology to simulation. In this paper we will present an outline of the methodology and give a simple example of its application to a two variable optimization problem.
S.J. Hood, P.D. Welch
openaire   +1 more source

Optimization of Electrochemiluminescence Experimental Conditions for Metoclopramide Determination Based on Response Surface Methodology

International Journal of Electrochemical Science, 2020
Based on the strongenhancement effect of metoclopramide on the electrochemiluminescencesignal of Ru(bpy)32+ on the platinum electrode, a novelmethod for the sensitive detection of metoclopramide was established.
Fuxiu Yang, Wenjuan Zhang, Baining Liu, Yizhi Ji, Youxi Zhao, Kaowen Zhou   +5 more
doaj   +1 more source

Optimization of ultrasound-assisted extraction of total polyphenolic compounds from Juglans nigra L. leaves [PDF]

Journal of the Serbian Chemical Society, 2018
The ultrasound-assisted extraction of Juglans nigra L. leaves was optimized with respect to total phenolic content (TP) of the extracts by varying the concentration of aqueous ethanol solution (E) and different solvent-to-solid ratio (S).
Gavrilović Marijana, Rajković Katarina M., Simić Valentina, Jeremić Sanja, Mirković Snježana, Jevtić Aleksandra S.   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Extraction and Functional Properties of Crude Prolamin from Amaranth

Foods
The objective of this study was to evaluate the structural, functional and morphological characterizations of ultrasonic-assisted extraction of crude prolamin from amaranth grain (Amaranthus hypochondriacus L.).
Yujun Dong, Xiaojun Hu, Yajuan Wang, Li He   +3 more
doaj   +1 more source