Results 51 to 60 of about 12,593,396 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using response-surface methodology to detect chaos in ecological time series

, 1993
The performance of Turchin and Taylor's response-surface methodology in characterizing the endogenous dynamics underlying ecological time series is studied for the aphid Phyllaphis fagi. The results are shown to be sensitive to further data from the same
Hanski, I., Perry, J. N., Woiwod, I. P.
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Intumescent fire retardant coating with recycled powder from industrial effluent optimized using response surface methodology

, 2020
With the rapid development of Al electrolytic capacitors, plenty of industrial effluents are generated during the corrosion process of aluminium anode, resulting in serious environmental problems.
Liu, Shi, Zhang, Qi, Wang, Cheng, Liu, Zhitian, Hu, Qinghua, Huo, Siqi   +5 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Surface roughness prediction in milling based on tool displacements [PDF]

, 2011
In this paper, an experimental device using non-contact displacement sensors for the investigation of milling tool behaviour is presented. It enables the recording of high frequency tool vibrations during milling operations.
MOREAU, Vincent, Jean Philippe Costes, Vincent Moreau, COSTES, Jean-Philippe   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Optimization of xylanase production by Sporotrichum thermophile using corn cobs and response surface methodology

, 2006
A 32 central composite experimental design was performed with the aim of optimizing the production of xylanase by Sporotrichum thermophile grown on corn cobs in submerged cultures.
Katapodis, P, Christakopoulos, P, Christakopoulou, V, Christakopoulos, Paul, Katapodis, P.,, Christakopoulo, V.,   +5 more
core   +1 more source

Biodiesel Production from Vegetable Oil over Plasma Reactor: Optimization of Biodiesel Yield using Response Surface Methodology [PDF]

, 2009
Biodiesel production has received considerable attention in the recent past as a renewable fuel. The production of biodiesel by conventional transesterification process employs alkali or acid catalyst and has been industrially accepted for its high ...
Nugroho, Bambang Tri, Istadi, Istadi, Marwoto, Putut, Suherman Suherman, Istadi Istadi, Suherman, Suherman, Bambang Tri Nugroho, Anggoro, Didi Dwi, Didi Dwi Anggoro, Putut Marwoto   +9 more
core   +2 more sources

Optimization of pectinase extraction from mango (Mangifera indica cv. Chokanan) peel using response surface methodology [PDF]

, 2013
Today pectinases (EC 3.2.1.15) have become an integral part of the food and feed industry and plant peel could be a potential source of pectinase. Thus, the main objective of the study was the optimization of pectinase extraction from mango (Mangifera ...
Abd. Manap, Mohd. Yazid, Mehrnoush, Amid
core   +1 more source