Results 31 to 40 of about 1,638,463 (351)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Synthesis and process optimization of electrospun PEEK-sulfonated nanofibers by response surface methodology [PDF]

, 2015
In this study electrospun nanofibers of partially sulfonated polyether ether ketone have been produced as a preliminary step for a possible development of composite proton exchange membranes for fuel cells.
Boaretti, Carlo, Lorenzetti, Alessandra, Modesti, Michele, Roso, Martina   +3 more
core   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Maximization of fructose esters synthesis by response surface methodology [PDF]

, 2011
Enzymatic synthesis of fructose fatty acide sterwasper formed inorganic solventmedia, using apurified lipase from Candida antartica B immobilizedinacrylicresin.
Neta, Nair do Amaral Sampaio, Peres, A. M., Rodrigues, L. R., Teixeira, J. A.   +3 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Effects of electrospinning parameters on polyacrylonitrile nanofiber diameter: an investigation by response surface methodology [PDF]

, 2008
Effects of material and process parameters on the diameter of electrospun polyacrylonitrile fibers were experimentally investigated. Response surface methodology (RSM) was utilized to design the experiments at the settings of solution concentration ...
Menceloglu, Yusuf Z., Menceloğlu, Yusuf Z., Papila, Melih, Yordem, Sinan Onur, Yördem, Sinan Onur   +4 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Extraction and Functional Properties of Crude Prolamin from Amaranth

Foods
The objective of this study was to evaluate the structural, functional and morphological characterizations of ultrasonic-assisted extraction of crude prolamin from amaranth grain (Amaranthus hypochondriacus L.).
Yujun Dong, Xiaojun Hu, Yajuan Wang, Li He   +3 more
doaj   +1 more source

WARPAGE ANALYSIS ON FRONT PANEL HOUSING USING RESPONSE SURFACE METHODOLOGY (RSM) [PDF]

European Journal of Materials Science and Engineering, 2016
The work reported herein is about a study to establish the best combination of injection moulding parameters in minimising warpage over a front panel housing using a simulation software.
Mohd Afiq HARUN, Shayfull Zamree ABD RAHIM, Mohd Nasir MAT SAAD, Mohd Fathullah GHAZALI   +3 more
doaj  

The Effect of Alkaline Treatment on Mechanical Performance of Natural Fibers-reinforced Plaster: Optimization Using RSM

Journal of Natural Fibers, 2021
In the last decades, eco-friendly materials are playing an interesting role. Particularly, many studies deal with the use of natural fibers as a replacement to synthetic fibers in the plaster matrix.
Messaouda Boumaaza, Ahmed Belaadi, Mostefa Bourchak   +2 more
doaj   +1 more source