Results 101 to 110 of about 15,971,534 (326)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

In Vitro Analysis of Bone Response to Different Implant Surface Roughness

Journal of Pharmacy and Bioallied Sciences
Background: The surface roughness of dental implants plays a critical role in osseointegration by enhancing bone-implant contact. However, the optimal surface topography to maximize bone response is still under investigation.
Sushma Sanjay Lagdive, Amit Vasani, Vibhuti Madhad, Satinder Pal Singh Tulsi, Abikshyeet Panda, Satya Prakash Gupta, Hiren Hansraj Patadiya, Honey Lunkad   +7 more
doaj   +1 more source

Response Surfaces Method and Artificial Intelligence Approaches for Modeling the Effects of Environmental Factors on Chlorophyll a in Isochrysis galbana. [PDF]

Microorganisms, 2023
Zhang L, Liu J, Shen X, Li S, Li W, Xiao X.   +5 more
europepmc   +1 more source

Localized Charge Transfer Process and Surface Band Bending in Methane Sensing by GaN Nanowires

, 2016
The physicochemical processes at the surfaces of semiconductor nanostructures involved in electrochemical and sensing devices are strongly influenced by the presence of intrinsic or extrinsic defects.
Amirthapandian, S., Cotta, M. A., Das, A., Dhara, S., Patsha, A., Prasad, A. K., Sahoo, P., Tyagi, A. K.   +7 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

On actions for (entangling) surfaces and DCFTs

, 2018
The dynamics of surfaces and interfaces describe many physical systems, including fluid membranes, entanglement entropy and the coupling of defects to quantum field theories.
Armas, Jay, Tarrio, Javier
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimización de curvas de crecimiento a través de análisis univariado

Revista Colombiana de Estadística, 2008
En este artículo se propone una metodología de modelamiento conjunto de tratamientos con niveles cuantitativos medidos en el tiempo, a través de la combinación de las metodologías de superficie de respuesta y curvas de crecimiento.
SARA CRISTINA GUERRERO, ÓSCAR ORLANDO MELO   +1 more
doaj  

Modeling synergistic effects by using general Hill-type response surfaces describing drug interactions. [PDF]

Sci Rep, 2022
Schindler M.
europepmc   +1 more source

Heat transfer device [PDF]

, 1974
A heat transfer device is characterized by an hermetically sealed tubular housing including a tubular shell terminating in spaced end plates, and a tubular mesh wick concentrically arranged and operatively supported within said housing.
Kalkbrenner, R. W.
core   +1 more source